COLL1_HUMAN
ID COLL1_HUMAN Reviewed; 121 AA.
AC A2RUU4; A7E2T6; B2RPE2; B5G4V2; B6ZDM9; Q5T9G1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Colipase-like protein 1;
DE Flags: Precursor;
GN Name=CLPSL1; Synonyms=C6orf127;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Epididymis;
RX PubMed=18390568; DOI=10.1093/dnares/dsn005;
RA Li J.Y., Wang H.Y., Liu J., Liu Q., Zhang J.S., Wan F.C., Liu F.J.,
RA Jin S.H., Zhang Y.L.;
RT "Transcriptome analysis of a cDNA library from adult human epididymis.";
RL DNA Res. 15:115-122(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|PROSITE-ProRule:PRU00674}.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in epididymis, in the corpus
CC region. {ECO:0000269|PubMed:18390568}.
CC -!- SIMILARITY: Belongs to the colipase family. {ECO:0000255|PROSITE-
CC ProRule:PRU00674}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK41022.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; DQ823638; ABK41022.1; ALT_FRAME; mRNA.
DR EMBL; AL157823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03849.1; -; Genomic_DNA.
DR EMBL; BC133046; AAI33047.1; -; mRNA.
DR EMBL; BC137392; AAI37393.1; -; mRNA.
DR EMBL; BC150543; AAI50544.1; -; mRNA.
DR EMBL; BC150544; AAI50545.1; -; mRNA.
DR CCDS; CCDS43456.1; -.
DR RefSeq; NP_001010886.1; NM_001010886.4.
DR AlphaFoldDB; A2RUU4; -.
DR SMR; A2RUU4; -.
DR BioGRID; 131012; 46.
DR IntAct; A2RUU4; 6.
DR STRING; 9606.ENSP00000362968; -.
DR iPTMnet; A2RUU4; -.
DR PhosphoSitePlus; A2RUU4; -.
DR BioMuta; CLPSL1; -.
DR MassIVE; A2RUU4; -.
DR PaxDb; A2RUU4; -.
DR PeptideAtlas; A2RUU4; -.
DR PRIDE; A2RUU4; -.
DR ProteomicsDB; 525; -.
DR Antibodypedia; 55276; 4 antibodies from 4 providers.
DR DNASU; 340204; -.
DR Ensembl; ENST00000373861.6; ENSP00000362968.5; ENSG00000204140.10.
DR GeneID; 340204; -.
DR KEGG; hsa:340204; -.
DR MANE-Select; ENST00000373861.6; ENSP00000362968.5; NM_001010886.5; NP_001010886.1.
DR UCSC; uc003old.5; human.
DR CTD; 340204; -.
DR DisGeNET; 340204; -.
DR GeneCards; CLPSL1; -.
DR HGNC; HGNC:21251; CLPSL1.
DR HPA; ENSG00000204140; Group enriched (epididymis, pancreas).
DR neXtProt; NX_A2RUU4; -.
DR OpenTargets; ENSG00000204140; -.
DR PharmGKB; PA134984810; -.
DR VEuPathDB; HostDB:ENSG00000204140; -.
DR eggNOG; ENOG502TDXY; Eukaryota.
DR GeneTree; ENSGT00510000049845; -.
DR HOGENOM; CLU_2037257_0_0_1; -.
DR InParanoid; A2RUU4; -.
DR OMA; RRAPDIC; -.
DR OrthoDB; 1517288at2759; -.
DR PhylomeDB; A2RUU4; -.
DR TreeFam; TF336178; -.
DR PathwayCommons; A2RUU4; -.
DR SignaLink; A2RUU4; -.
DR BioGRID-ORCS; 340204; 11 hits in 1061 CRISPR screens.
DR GenomeRNAi; 340204; -.
DR Pharos; A2RUU4; Tdark.
DR PRO; PR:A2RUU4; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; A2RUU4; protein.
DR Bgee; ENSG00000204140; Expressed in body of pancreas and 68 other tissues.
DR ExpressionAtlas; A2RUU4; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR GO; GO:0007586; P:digestion; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR GO; GO:0032094; P:response to food; IBA:GO_Central.
DR InterPro; IPR001981; Colipase.
DR PANTHER; PTHR10041; PTHR10041; 1.
DR PRINTS; PR00128; COLIPASE.
DR SMART; SM00023; COLIPASE; 1.
DR PROSITE; PS51342; COLIPASE_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..121
FT /note="Colipase-like protein 1"
FT /id="PRO_0000337013"
FT DISULFID 39..50
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 45..61
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 49..83
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 71..91
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 85..107
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT VARIANT 15
FT /note="F -> S (in dbSNP:rs34109614)"
FT /id="VAR_043560"
FT CONFLICT 92
FT /note="I -> M (in Ref. 4; AAI50545)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 121 AA; 14057 MW; D73C9F747B130656 CRC64;
MMLPQWLLLL FLLFFFLFLL TRGSLSPTKY NLLELKESCI RNQDCETGCC QRAPDNCESH
CAEKGSEGSL CQTQVFFGQY RACPCLRNLT CIYSKNEKWL SIAYGRCQKI GRQKLAKKMF
F
