COLL2_HUMAN
ID COLL2_HUMAN Reviewed; 100 AA.
AC Q6UWE3; B0QZ45; Q5T9G3;
DT 09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Colipase-like protein 2;
DE Flags: Precursor;
GN Name=CLPSL2; Synonyms=C6orf126; ORFNames=UNQ3045/PRO9861;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP PROTEIN SEQUENCE OF 22-35.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- INTERACTION:
CC Q6UWE3; Q9UHD9: UBQLN2; NbExp=6; IntAct=EBI-12183429, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UWE3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UWE3-2; Sequence=VSP_035621;
CC -!- SIMILARITY: Belongs to the colipase family. {ECO:0000255|PROSITE-
CC ProRule:PRU00674}.
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DR EMBL; AY358823; AAQ89182.1; -; mRNA.
DR EMBL; AL157823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS4810.2; -. [Q6UWE3-1]
DR CCDS; CCDS69095.1; -. [Q6UWE3-2]
DR RefSeq; NP_001273479.1; NM_001286550.1. [Q6UWE3-2]
DR RefSeq; NP_997292.2; NM_207409.3. [Q6UWE3-1]
DR AlphaFoldDB; Q6UWE3; -.
DR SMR; Q6UWE3; -.
DR BioGRID; 133118; 2.
DR IntAct; Q6UWE3; 1.
DR STRING; 9606.ENSP00000353639; -.
DR iPTMnet; Q6UWE3; -.
DR PhosphoSitePlus; Q6UWE3; -.
DR BioMuta; CLPSL2; -.
DR DMDM; 212276514; -.
DR PaxDb; Q6UWE3; -.
DR PeptideAtlas; Q6UWE3; -.
DR PRIDE; Q6UWE3; -.
DR TopDownProteomics; Q6UWE3-2; -. [Q6UWE3-2]
DR Antibodypedia; 64892; 1 antibodies from 1 providers.
DR DNASU; 389383; -.
DR Ensembl; ENST00000360454.6; ENSP00000353639.2; ENSG00000196748.10. [Q6UWE3-2]
DR Ensembl; ENST00000403376.4; ENSP00000385898.3; ENSG00000196748.10. [Q6UWE3-1]
DR GeneID; 389383; -.
DR KEGG; hsa:389383; -.
DR MANE-Select; ENST00000403376.4; ENSP00000385898.3; NM_207409.4; NP_997292.2.
DR UCSC; uc003olc.3; human. [Q6UWE3-1]
DR CTD; 389383; -.
DR DisGeNET; 389383; -.
DR GeneCards; CLPSL2; -.
DR HGNC; HGNC:21250; CLPSL2.
DR HPA; ENSG00000196748; Tissue enriched (epididymis).
DR neXtProt; NX_Q6UWE3; -.
DR OpenTargets; ENSG00000196748; -.
DR PharmGKB; PA134977993; -.
DR VEuPathDB; HostDB:ENSG00000196748; -.
DR eggNOG; ENOG502TDRC; Eukaryota.
DR GeneTree; ENSGT00390000011494; -.
DR HOGENOM; CLU_1730871_0_0_1; -.
DR InParanoid; Q6UWE3; -.
DR OMA; SDCCLMD; -.
DR OrthoDB; 1355226at2759; -.
DR PhylomeDB; Q6UWE3; -.
DR TreeFam; TF343049; -.
DR PathwayCommons; Q6UWE3; -.
DR SignaLink; Q6UWE3; -.
DR BioGRID-ORCS; 389383; 18 hits in 1065 CRISPR screens.
DR ChiTaRS; CLPSL2; human.
DR GenomeRNAi; 389383; -.
DR Pharos; Q6UWE3; Tdark.
DR PRO; PR:Q6UWE3; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q6UWE3; protein.
DR Bgee; ENSG00000196748; Expressed in body of pancreas and 53 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR GO; GO:0007586; P:digestion; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR GO; GO:0032094; P:response to food; IBA:GO_Central.
DR InterPro; IPR001981; Colipase.
DR PANTHER; PTHR10041; PTHR10041; 1.
DR PROSITE; PS51342; COLIPASE_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Direct protein sequencing; Disulfide bond;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 22..100
FT /note="Colipase-like protein 2"
FT /id="PRO_0000022608"
FT DISULFID 34..45
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 40..56
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 44..78
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 66..86
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 80..97
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT VAR_SEQ 70..100
FT /note="TKGATNIICPCRMGLTCISKDLMCSRRCHMI -> WLELFKGRDRIIFIYEA
FT PTPSLVSAHNQGSYQHHLPLPDGLDVHIQGLDVFPPVPYDLEEDAGWSLLPWGHRPWLP
FT PTCSKSSS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_035621"
FT CONFLICT Q6UWE3-2:79
FT /note="R -> C (in Ref. 1; AAQ89182)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 100 AA; 10812 MW; 2458FFEA1F48C563 CRC64;
MAAALALVAG VLSGAVLPLW SALPQYKKKI TDRCFHHSEC YSGCCLMDLD SGGAFCAPRA
RITMICLPQT KGATNIICPC RMGLTCISKD LMCSRRCHMI
