COLL2_MOUSE
ID COLL2_MOUSE Reviewed; 102 AA.
AC Q3UW21;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Colipase-like protein 2;
DE Flags: Precursor;
GN Name=Clpsl2; Synonyms=Gm749;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Epididymis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the colipase family. {ECO:0000255|PROSITE-
CC ProRule:PRU00674}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK136682; BAE23098.1; -; mRNA.
DR EMBL; CT009661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC147116; AAI47117.1; -; mRNA.
DR EMBL; BC147117; AAI47118.1; -; mRNA.
DR CCDS; CCDS50047.1; -.
DR RefSeq; NP_001030043.1; NM_001034871.2.
DR AlphaFoldDB; Q3UW21; -.
DR SMR; Q3UW21; -.
DR STRING; 10090.ENSMUSP00000025061; -.
DR PhosphoSitePlus; Q3UW21; -.
DR PaxDb; Q3UW21; -.
DR PRIDE; Q3UW21; -.
DR ProteomicsDB; 283491; -.
DR Antibodypedia; 64892; 1 antibodies from 1 providers.
DR Ensembl; ENSMUST00000025061; ENSMUSP00000025061; ENSMUSG00000024224.
DR GeneID; 328788; -.
DR KEGG; mmu:328788; -.
DR UCSC; uc008bre.1; mouse.
DR CTD; 389383; -.
DR MGI; MGI:2685595; Clpsl2.
DR VEuPathDB; HostDB:ENSMUSG00000024224; -.
DR eggNOG; ENOG502TFBF; Eukaryota.
DR GeneTree; ENSGT00390000011494; -.
DR HOGENOM; CLU_183899_0_0_1; -.
DR InParanoid; Q3UW21; -.
DR OMA; SDCCLMD; -.
DR OrthoDB; 1540517at2759; -.
DR PhylomeDB; Q3UW21; -.
DR TreeFam; TF343049; -.
DR BioGRID-ORCS; 328788; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q3UW21; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q3UW21; protein.
DR Bgee; ENSMUSG00000024224; Expressed in morula and 4 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR GO; GO:0007586; P:digestion; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR GO; GO:0032094; P:response to food; IBA:GO_Central.
DR InterPro; IPR001981; Colipase.
DR PANTHER; PTHR10041; PTHR10041; 1.
DR PROSITE; PS51342; COLIPASE_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000250"
FT CHAIN 24..102
FT /note="Colipase-like protein 2"
FT /id="PRO_0000352880"
FT DISULFID 36..47
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 42..58
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 46..80
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 68..88
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 82..99
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
SQ SEQUENCE 102 AA; 11027 MW; 025891AEC4805B48 CRC64;
MAFTQALVTV LALLAGTLPH RHSENSPPKK ANGDKCVHHT QCSSDCCLID LERSGAFCTP
KSRIGMGCLP QTKGSLNIMC PCRSGLNCHS KDPTCPRRCQ MI
