COLL2_RAT
ID COLL2_RAT Reviewed; 104 AA.
AC D3ZVN1;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Colipase-like protein 2;
DE Flags: Precursor;
GN Name=Clpsl2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the colipase family. {ECO:0000255|PROSITE-
CC ProRule:PRU00674}.
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DR EMBL; AABR03116945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001128474.1; NM_001135002.1.
DR AlphaFoldDB; D3ZVN1; -.
DR SMR; D3ZVN1; -.
DR STRING; 10116.ENSRNOP00000056057; -.
DR PaxDb; D3ZVN1; -.
DR Ensembl; ENSRNOT00000059292; ENSRNOP00000056057; ENSRNOG00000038807.
DR GeneID; 689425; -.
DR KEGG; rno:689425; -.
DR UCSC; RGD:1592336; rat.
DR CTD; 389383; -.
DR RGD; 1592336; Clpsl2.
DR eggNOG; ENOG502TFBF; Eukaryota.
DR GeneTree; ENSGT00390000011494; -.
DR HOGENOM; CLU_183899_0_0_1; -.
DR InParanoid; D3ZVN1; -.
DR OMA; SDCCLMD; -.
DR OrthoDB; 1540517at2759; -.
DR PhylomeDB; D3ZVN1; -.
DR TreeFam; TF343049; -.
DR PRO; PR:D3ZVN1; -.
DR Proteomes; UP000002494; Chromosome 20.
DR Bgee; ENSRNOG00000038807; Expressed in pancreas and 7 other tissues.
DR ExpressionAtlas; D3ZVN1; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR GO; GO:0007586; P:digestion; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR GO; GO:0032094; P:response to food; IBA:GO_Central.
DR InterPro; IPR001981; Colipase.
DR PANTHER; PTHR10041; PTHR10041; 1.
DR PROSITE; PS51342; COLIPASE_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000250"
FT CHAIN 20..104
FT /note="Colipase-like protein 2"
FT /id="PRO_0000416691"
FT DISULFID 38..49
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 44..60
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 48..82
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 70..90
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT DISULFID 84..101
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
SQ SEQUENCE 104 AA; 11495 MW; 2C516012819F0601 CRC64;
MAFTQALVTV LAFLVGTLPH KFDFSENSDL KKANGDKCVH HSQCFSDCCL IDLERSGAFC
TSKSHVGMAC LPQTKRSLNI LCPCRIGLSC HSKDPMCPRR CQMI
