ID   COLUA_COLDE             Reviewed;           7 AA.
AC   P86168;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Colutellin-A;
DE   Flags: Fragments;
OS   Colletotrichum dematium (Anthracnose fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC   Colletotrichum dematium species complex.
OX   NCBI_TaxID=34405;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RX   PubMed=18599825; DOI=10.1099/mic.0.2008/017954-0;
RA   Ren Y., Strobel G.A., Graff J.C., Jutila M., Park S.G., Gosh S., Teplow D.,
RA   Condron M., Pang E., Hess W.M., Moore E.;
RT   "Colutellin A, an immunosuppressive peptide from Colletotrichum dematium.";
RL   Microbiology 154:1973-1979(2008).
CC   -!- FUNCTION: Has antifungal activity against S.sclerotiorum (MIC=32.4
CC       ug/ml after 288 hours) and B.cinerea (MIC=10.8 ug/ml after 288 hours),
CC       and weak antifungal activity against F.solani, A.fumigatus and
CC       G.candidum. Lacks antifungal activity against P.ultimum, T.viride and
CC       R.solani. Inhibits the production of interleukin-2 by activated CD4+ T-
CC       cells with an IC(50) of 167.3 nM. Lacks cytotoxic activity against
CC       human peripheral blood mononuclear cells.
CC       {ECO:0000269|PubMed:18599825}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18599825}.
CC   -!- MASS SPECTROMETRY: Mass=1095.7; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:18599825};
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DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   GO; GO:0032703; P:negative regulation of interleukin-2 production; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Antimicrobial; Direct protein sequencing; Fungicide; Secreted.
FT   PEPTIDE         1..>7
FT                   /note="Colutellin-A"
FT                   /id="PRO_0000363941"
FT   NON_CONS        4..5
FT                   /evidence="ECO:0000303|PubMed:18599825"
FT   NON_TER         7
FT                   /evidence="ECO:0000303|PubMed:18599825"
SQ   SEQUENCE   7 AA;  740 MW;  72D7605045B042A0 CRC64;
     VISIIPV