ID   COL_ICTTR               Reviewed;         111 AA.
AC   Q91XL7;
DT   25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Colipase;
DE   Flags: Precursor;
GN   Name=CLPS;
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pancreas;
RA   Squire T.L., Bauer V.W., Lowe M.E., Andrews M.T.;
RT   "Genomic organization of the pancreatic triacylglycerol lipase gene in a
RT   hibernating mammal.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Colipase is a cofactor of pancreatic lipase. It allows the
CC       lipase to anchor itself to the lipid-water interface. Without colipase
CC       the enzyme is washed off by bile salts, which have an inhibitory effect
CC       on the lipase. {ECO:0000250|UniProtKB:P04118}.
CC   -!- FUNCTION: Enterostatin has a biological activity as a satiety signal.
CC       {ECO:0000250|UniProtKB:P04118}.
CC   -!- SUBUNIT: Forms a 1:1 stoichiometric complex with pancreatic lipase.
CC       {ECO:0000250|UniProtKB:P04118}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the pancreas.
CC   -!- SIMILARITY: Belongs to the colipase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00674}.
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DR   EMBL; AF395869; AAK72258.1; -; mRNA.
DR   RefSeq; NP_001269178.1; NM_001282249.1.
DR   AlphaFoldDB; Q91XL7; -.
DR   SMR; Q91XL7; -.
DR   STRING; 43179.ENSSTOP00000021080; -.
DR   Ensembl; ENSSTOT00000026093; ENSSTOP00000021080; ENSSTOG00000027903.
DR   GeneID; 101966377; -.
DR   CTD; 1208; -.
DR   eggNOG; ENOG502S4NY; Eukaryota.
DR   GeneTree; ENSGT00390000012644; -.
DR   HOGENOM; CLU_165591_0_0_1; -.
DR   InParanoid; Q91XL7; -.
DR   OMA; NSIQCKS; -.
DR   OrthoDB; 1504784at2759; -.
DR   TreeFam; TF336178; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR   GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR   CDD; cd00039; COLIPASE; 1.
DR   InterPro; IPR001981; Colipase.
DR   InterPro; IPR017914; Colipase_C.
DR   InterPro; IPR017915; Colipase_CS.
DR   InterPro; IPR017913; Colipase_N.
DR   PANTHER; PTHR10041; PTHR10041; 1.
DR   Pfam; PF01114; Colipase; 1.
DR   Pfam; PF02740; Colipase_C; 1.
DR   PRINTS; PR00128; COLIPASE.
DR   SMART; SM00023; COLIPASE; 1.
DR   PROSITE; PS00121; COLIPASE_1; 1.
DR   PROSITE; PS51342; COLIPASE_2; 1.
PE   2: Evidence at transcript level;
KW   Digestion; Disulfide bond; Lipid degradation; Lipid metabolism;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000250"
FT   PROPEP          17..21
FT                   /note="Enterostatin, activation peptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000005708"
FT   CHAIN           22..111
FT                   /note="Colipase"
FT                   /id="PRO_0000005709"
FT   DISULFID        33..44
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT   DISULFID        39..55
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT   DISULFID        43..77
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT   DISULFID        65..85
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT   DISULFID        79..103
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
SQ   SEQUENCE   111 AA;  12056 MW;  1C01F67B22F1ADAB CRC64;
     MKVLVLLLVT LAVVYAAPDP RGILINLEDG EICMNSAQCK SSCCQHFSPL GVARCTRKAS
     ENSECSPKTL YGIYYKCPCE RGLTCESDRT IIGAITNTNY GICLDAGRSK E