ID   COL_SQUAC               Reviewed;          39 AA.
AC   P11149;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Colipase;
DE   Flags: Fragment;
OS   Squalus acanthias (Spiny dogfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Squalomorphii; Squaliformes; Squalidae; Squalus.
OX   NCBI_TaxID=7797;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   PubMed=6477928; DOI=10.1016/0167-4838(84)90200-0;
RA   Sternby B., Engstroem A., Hellman U.;
RT   "Purification and characterization of pancreatic colipase from the dogfish
RT   (Squalus acanthius).";
RL   Biochim. Biophys. Acta 789:159-163(1984).
CC   -!- FUNCTION: Colipase is a cofactor of pancreatic lipase. It allows the
CC       lipase to anchor itself to the lipid-water interface. Without colipase
CC       the enzyme is washed off by bile salts, which have an inhibitory effect
CC       on the lipase.
CC   -!- SUBUNIT: Forms a 1:1 stoichiometric complex with pancreatic lipase.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the pancreas.
CC   -!- SIMILARITY: Belongs to the colipase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00674}.
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DR   PIR; A05331; A05331.
DR   AlphaFoldDB; P11149; -.
DR   SMR; P11149; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR   GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001981; Colipase.
DR   InterPro; IPR017913; Colipase_N.
DR   Pfam; PF01114; Colipase; 1.
DR   PRINTS; PR00128; COLIPASE.
DR   PROSITE; PS51342; COLIPASE_2; 1.
PE   1: Evidence at protein level;
KW   Digestion; Direct protein sequencing; Disulfide bond; Lipid degradation;
KW   Lipid metabolism; Secreted.
FT   CHAIN           1..>39
FT                   /note="Colipase"
FT                   /id="PRO_0000144832"
FT   DISULFID        16..27
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT   DISULFID        22..38
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00674"
FT   NON_TER         39
SQ   SEQUENCE   39 AA;  4107 MW;  ABCC4DF25E02101F CRC64;
     APERGLFLNL SAGELCVGSF QCKSSCCQRE TGLSLARCA