ID   COMA_CONIM              Reviewed;          71 AA.
AC   P0CH39;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Im-conomarphin;
DE   Flags: Precursor;
OS   Conus imperialis (Imperial cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX   NCBI_TaxID=35631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=20307606; DOI=10.1016/j.peptides.2010.03.010;
RA   Wu X.-C., Zhou M., Peng C., Shao X.-X., Guo Z.-Y., Chi C.-W.;
RT   "Novel conopeptides in a form of disulfide-crosslinked dimer.";
RL   Peptides 31:1001-1006(2010).
CC   -!- FUNCTION: May act as a neurotoxin.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- MISCELLANEOUS: The mature peptide does not contain cysteine residue.
CC   -!- MISCELLANEOUS: The amino acid sequence of Im-conomarphin is identical
CC       to that of C.marmoreus conomarphin (AC B2KPN7). Their nucleotide
CC       sequences are not identical.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0CH39; -.
DR   SMR; P0CH39; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; D-amino acid; Hydroxylation;
KW   Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..51
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000397198"
FT   PEPTIDE         55..69
FT                   /note="Im-conomarphin"
FT                   /id="PRO_0000397199"
FT   PROPEP          70..71
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000397200"
FT   REGION          27..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         64
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         67
FT                   /note="D-phenylalanine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   71 AA;  8325 MW;  190447838FFA04C3 CRC64;
     MMSKLGVLLC IFLVLFPMAT LQLDGDQTAD RHADQRGQDL TEQQRNSKRV LKKRDWEYHA
     HPKPNSFWTL V