ID   COMA_NEIGO              Reviewed;         691 AA.
AC   P51973;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Competence protein ComA;
GN   Name=comA;
OS   Neisseria gonorrhoeae.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7934834; DOI=10.1111/j.1365-2958.1993.tb00942.x;
RA   Facius D., Meyer T.F.;
RT   "A novel determinant (comA) essential for natural transformation competence
RT   in Neisseria gonorrhoeae and the effect of a comA defect on pilin
RT   variation.";
RL   Mol. Microbiol. 10:699-712(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MS11A;
RX   PubMed=8830266; DOI=10.1046/j.1365-2958.1996.457984.x;
RA   Fussenegger M., Facius D., Meier J., Meyer T.F.;
RT   "A novel peptidoglycan-linked lipoprotein (ComL) that functions in natural
RT   transformation competence of Neisseria gonorrhoeae.";
RL   Mol. Microbiol. 19:1095-1105(1996).
CC   -!- FUNCTION: Essential for natural transformation. Could be a transporter
CC       involved in DNA uptake.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI.
CC       {ECO:0000305}.
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DR   EMBL; S75490; AAB32261.1; -; Genomic_DNA.
DR   EMBL; Z49895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; S39867; S39867.
DR   AlphaFoldDB; P51973; -.
DR   SMR; P51973; -.
DR   TCDB; 3.A.11.2.1; the bacterial competence-related dna transformation transporter (dna-t) family.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR   CDD; cd07731; ComA-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR035681; ComA-like_MBL.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR004797; Competence_ComEC/Rec2.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
DR   TIGRFAMs; TIGR00360; ComEC_N-term; 1.
DR   TIGRFAMs; TIGR00361; ComEC_Rec2; 1.
PE   4: Predicted;
KW   Cell inner membrane; Cell membrane; Competence; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..691
FT                   /note="Competence protein ComA"
FT                   /id="PRO_0000090004"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   691 AA;  74358 MW;  C8B8CC7601A347FE CRC64;
     MLCVLAGAAY GVFRTEAALS SQWRAEAVSG VPLTVEVTDM PRSDGRRVQF AAKAVDSGGR
     TFDLLLSDYK RREWAVGSRW RITARVHPVV GELNLRGLNR EAWALSNGVG GVGTVGADRV
     LLHGGSGWGI AVWRSRISRN WRQADADGGL SDGIGLMRAL SVGEQSALRP GLWQAFRPLG
     LTHLVSISGL HVTMVAVLFA WLAKRLLACS PRLPARPRAW VLAAGCAGAL FYALLAGFSV
     PTQRSVLMLA AFAWAWRRGR LSAWATWWQA LAAVLLFDPL AVLGVGTWLS FGLVAALIWA
     CAGRLYEGKR QTAVRGQWAA SVLSLVLLGY LFASLPLVSP LVNAVSIPWF SWVLTPLALL
     GSVVPFAPLQ QAGAFLAEYT LRFLVWLADV SPEFAVAAAP LPLLVLAVCA ALLLLLPRGL
     GLRPWAVLLL AGFVSYRPEA VPENEAAVTV WDAGQGLSVL VRTANRHLLF DTGTVAAAQT
     GIVPSLNAAG VRRLDKLVLS HHDSDHDGGF QAVGKIPNGG IYAGQPEFYE GARHCAEQRW
     QWDGVDFEFL RPSERKNIDD NGKSCVLRVV AGGAALLVTG DLDTKGEESL VGKYGGNLYS
     QVLVLGHHGS NTSSSGVFLN AVSPEYAVAS SGYANAYKHP TEAVQNRVRA HGIKLLRTDL
     SGALQFGLGR GGVKAQRLRV YKFYWQKKPF E