ID   COMB_CONMA              Reviewed;          42 AA.
AC   Q9TWL8;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   02-JUN-2021, entry version 47.
DE   RecName: Full=Conodipine-M beta chain;
OS   Conus magus (Magical cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=6492;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=7876086; DOI=10.1074/jbc.270.8.3518;
RA   McIntosh J.M., Ghomashchi F., Gelb M.H., Dooley D.J., Stoehr S.J.,
RA   Giordani A.B., Naisbitt S.R., Olivera B.M.;
RT   "Conodipine-M, a novel phospholipase A2 isolated from the venom of the
RT   marine snail Conus magus.";
RL   J. Biol. Chem. 270:3518-3526(1995).
CC   -!- FUNCTION: Heterodimer: conodipine-M catalyzes the calcium-dependent
CC       hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This
CC       activity may be supported by the alpha chain. Conodipine-M inhibits the
CC       binding of isradipine (a ligand specific for L-type calcium channel) to
CC       L-type calcium channels. {ECO:0000269|PubMed:7876086}.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chains; probably disulfide-
CC       linked.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- MASS SPECTROMETRY: Mass=5036; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:7876086};
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DR   ConoServer; 5540; Conodipine-M beta chain.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0016042; P:lipid catabolic process; IDA:CACAO.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   CHAIN           1..42
FT                   /note="Conodipine-M beta chain"
FT                   /id="PRO_0000086875"
SQ   SEQUENCE   42 AA;  4962 MW;  F1132A5CEB974134 CRC64;
     AATCTHWALI YFKTVQLFGW XHFNYQVDAT YCPQFQPCMP XX