ID   COMB_STRCO              Reviewed;         237 AA.
AC   Q9F3E6;
DT   05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   17-JAN-2003, sequence version 3.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Probable 2-phosphosulfolactate phosphatase;
DE            EC=3.1.3.71;
GN   Name=comB; OrderedLocusNames=SCO7611; ORFNames=SC2H2.09;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate +
CC         phosphate; Xref=Rhea:RHEA:23416, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15597, ChEBI:CHEBI:43474, ChEBI:CHEBI:58738; EC=3.1.3.71;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the ComB family. {ECO:0000305}.
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DR   EMBL; AL939132; CAC16713.1; -; Genomic_DNA.
DR   RefSeq; NP_631652.1; NC_003888.3.
DR   RefSeq; WP_003971533.1; NZ_VNID01000005.1.
DR   AlphaFoldDB; Q9F3E6; -.
DR   SMR; Q9F3E6; -.
DR   STRING; 100226.SCO7611; -.
DR   GeneID; 1103049; -.
DR   KEGG; sco:SCO7611; -.
DR   PATRIC; fig|100226.15.peg.7728; -.
DR   eggNOG; COG2045; Bacteria.
DR   HOGENOM; CLU_070028_1_0_11; -.
DR   InParanoid; Q9F3E6; -.
DR   OMA; CAQYIAR; -.
DR   PhylomeDB; Q9F3E6; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0050532; F:2-phosphosulfolactate phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0050545; F:sulfopyruvate decarboxylase activity; IBA:GO_Central.
DR   Gene3D; 3.90.1560.10; -; 1.
DR   HAMAP; MF_00490; ComB; 1.
DR   InterPro; IPR005238; ComB-like.
DR   InterPro; IPR036702; ComB-like_sf.
DR   PANTHER; PTHR37311; PTHR37311; 1.
DR   Pfam; PF04029; 2-ph_phosp; 1.
DR   SUPFAM; SSF142823; SSF142823; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium; Reference proteome.
FT   CHAIN           1..237
FT                   /note="Probable 2-phosphosulfolactate phosphatase"
FT                   /id="PRO_0000081472"
SQ   SEQUENCE   237 AA;  24800 MW;  91B50DF45D6F7017 CRC64;
     MLPGVRDHDG MDTRFVGIPE VGEAPAVAVV VDVMRAFTVA AWAFARGAEK IVLAGSLDEA
     LALKERDPAR VALKDGPLTP GFDLVNSPGL LRSADLAGRT VVQKTTAGTV GALAVRDASL
     VLCAGFVVAE ATARVLRARA PEHVTFVVTG EDGRADEDLA CARYIARRAA GHDADAAGFL
     GRAAESRAAT ELVQGVRQGV HPDDVALCLE LDRFPFAMVA APEDSLMVLR PCAVPRP