ID   COMB_STRR6              Reviewed;         449 AA.
AC   P59654;
DT   30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   30-APR-2003, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Transport protein ComB;
GN   Name=comB; OrderedLocusNames=spr0044;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
CC   -!- FUNCTION: Required for induction of competence. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000305}.
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DR   EMBL; AE007317; AAK98848.1; -; Genomic_DNA.
DR   RefSeq; NP_357638.1; NC_003098.1.
DR   RefSeq; WP_000801613.1; NC_003098.1.
DR   AlphaFoldDB; P59654; -.
DR   SMR; P59654; -.
DR   STRING; 171101.spr0044; -.
DR   EnsemblBacteria; AAK98848; AAK98848; spr0044.
DR   GeneID; 60233906; -.
DR   KEGG; spr:spr0044; -.
DR   PATRIC; fig|171101.6.peg.52; -.
DR   eggNOG; COG0845; Bacteria.
DR   HOGENOM; CLU_047946_0_0_9; -.
DR   OMA; HINDEYS; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR   InterPro; IPR005696; MesE/LcnD.
DR   TIGRFAMs; TIGR01000; bacteriocin_acc; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Competence; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..449
FT                   /note="Transport protein ComB"
FT                   /id="PRO_0000201865"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..449
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   449 AA;  49613 MW;  3EEE145EF71C159E CRC64;
     MKPEFLESAE FYNRRYHNFS SSVIVPMALL LVFLLGFATV AEKEMSLSTR ATVEPSRILA
     NIQSTSNNRI LVNHLEENKL VKKGDLLVQY QEGAEGVQAE SYASQLDMLK DQKKQLEYLQ
     KSLQEGENHF PEEDKFGYQA TFRDYISQAG SLRASTSQQN ETIASQNAAA SQTQAEIGNL
     ISQTEAKIRD YQTAKSAIET GTSLAGQNLA YSLYQSYKSQ GEENPQTKVQ AVAQVEAQIS
     QLESSLATYR VQYAGSGTQQ AYASGLSSQL ESLKSQHLAK VGQELSLLAQ KILEAESGKK
     VQGNLLDKGK ITASEDGVLH LNPETSDSSM VAEGTLLAQL YPSLEREGKA KLTAYLSSKD
     VARIKVGDSV RYTTTHDAGN QLFLDSTITS IDATATKTEK GNFFKIEAET NLTSEQAEKL
     RYGVEGRLQM ITGKKSYLRY YLDQFLNKE