ID   2ABD_XENTR              Reviewed;         447 AA.
AC   Q6DIY3;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform;
DE   AltName: Full=PP2A subunit B isoform B55-delta;
DE   AltName: Full=PP2A subunit B isoform PR55-delta;
DE   AltName: Full=PP2A subunit B isoform R2-delta;
DE   AltName: Full=PP2A subunit B isoform delta;
GN   Name=ppp2r2d;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: B regulatory subunit of protein phosphatase 2A (PP2A) that
CC       plays a key role in cell cycle by controlling mitosis entry and exit.
CC       The activity of PP2A complexes containing ppp2r2d (PR55-delta)
CC       fluctuate during the cell cycle: the activity is high in interphase and
CC       low in mitosis. During mitosis, activity of PP2A is inhibited via
CC       interaction with phosphorylated ensa and arpp19 inhibitors. PP2A
CC       complexes containing ppp2r2d (PR55-delta) also regulate the activity of
CC       TGF-beta/Activin/Nodal signaling by restricting receptor activity.
CC       Within the PP2A complexes, the B regulatory subunits modulate substrate
CC       selectivity and catalytic activity, and also may direct the
CC       localization of the catalytic enzyme to a particular subcellular
CC       compartment (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed
CC       of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant
CC       regulatory subunit (PR65 or subunit A), that associates with a variety
CC       of regulatory subunits. Proteins that associate with the core dimer
CC       include three families of regulatory subunits B (the R2/B/PR55/B55,
CC       R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable
CC       regulatory subunit, viral proteins, and cell signaling molecules.
CC       Interacts with ensa (when phosphorylated at 'Ser-67') and arpp19 (when
CC       phosphorylated at 'Ser-67'), leading to inhibit PP2A activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B family.
CC       {ECO:0000305}.
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DR   EMBL; BC075402; AAH75402.1; -; mRNA.
DR   RefSeq; NP_001006697.1; NM_001006696.1.
DR   AlphaFoldDB; Q6DIY3; -.
DR   SMR; Q6DIY3; -.
DR   STRING; 8364.ENSXETP00000059786; -.
DR   PRIDE; Q6DIY3; -.
DR   Ensembl; ENSXETT00000011981; ENSXETP00000011981; ENSXETG00000005442.
DR   GeneID; 448324; -.
DR   KEGG; xtr:448324; -.
DR   CTD; 55844; -.
DR   Xenbase; XB-GENE-940312; ppp2r2d.
DR   eggNOG; KOG1354; Eukaryota.
DR   InParanoid; Q6DIY3; -.
DR   OrthoDB; 810409at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000005442; Expressed in ovary and 14 other tissues.
DR   ExpressionAtlas; Q6DIY3; baseline.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0000159; C:protein phosphatase type 2A complex; ISS:UniProtKB.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0010458; P:exit from mitosis; ISS:UniProtKB.
DR   GO; GO:0000278; P:mitotic cell cycle; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR000009; PP2A_PR55.
DR   InterPro; IPR018067; PP2A_PR55_CS.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR11871; PTHR11871; 1.
DR   PIRSF; PIRSF037309; PP2A_PR55; 1.
DR   PRINTS; PR00600; PP2APR55.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS01024; PR55_1; 1.
DR   PROSITE; PS01025; PR55_2; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; Mitosis; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..447
FT                   /note="Serine/threonine-protein phosphatase 2A 55 kDa
FT                   regulatory subunit B delta isoform"
FT                   /id="PRO_0000408326"
FT   REPEAT          26..65
FT                   /note="WD 1"
FT   REPEAT          91..132
FT                   /note="WD 2"
FT   REPEAT          175..213
FT                   /note="WD 3"
FT   REPEAT          224..264
FT                   /note="WD 4"
FT   REPEAT          283..321
FT                   /note="WD 5"
FT   REPEAT          338..379
FT                   /note="WD 6"
FT   REPEAT          414..447
FT                   /note="WD 7"
SQ   SEQUENCE   447 AA;  51678 MW;  D0BEE3CA74503492 CRC64;
     MAGVGGGNDF QWCFSQVKGA IDEDVAEADI ISTVEFNCSG DLLATGDKGG RVVIFQREQE
     NKSRPHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQQNAAHF LLSTNDKTIK
     LWKISERDKR VEGYNLKDDD GRLRDPFRIT SLRVPILKPM DLMVEASPRR IFANAHTYHI
     NSISVNSDHE TYLSADDLRI NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPHHCN
     VFVYSSSKGT IRLCDMRDSA LCDRHSKFFE EPEDPSSRSF FSEIISSISD VKFSNSGRYM
     MTRDYLSVKV WDLNMESRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW NGSDSAIMTG
     SYNNFFRMFD RNTRRDITLE ASRESSKPRA ILKPRKVCTG GKRKKDEINV DSLDFNKKIL
     HTAWHPTDNI IAVAATNNLY IFQDKVN