COMB_THET2
ID COMB_THET2 Reviewed; 237 AA.
AC Q72IQ9;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Probable 2-phosphosulfolactate phosphatase {ECO:0000255|HAMAP-Rule:MF_00490};
DE EC=3.1.3.71 {ECO:0000255|HAMAP-Rule:MF_00490};
GN Name=comB {ECO:0000255|HAMAP-Rule:MF_00490}; OrderedLocusNames=TT_C1073;
OS Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27).
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=262724;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-163 / DSM 7039 / HB27;
RX PubMed=15064768; DOI=10.1038/nbt956;
RA Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H.,
RA Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C.,
RA Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P.,
RA Kramer W., Merkl R., Gottschalk G., Fritz H.-J.;
RT "The genome sequence of the extreme thermophile Thermus thermophilus.";
RL Nat. Biotechnol. 22:547-553(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate +
CC phosphate; Xref=Rhea:RHEA:23416, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15597, ChEBI:CHEBI:43474, ChEBI:CHEBI:58738; EC=3.1.3.71;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00490};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00490};
CC -!- SIMILARITY: Belongs to the ComB family. {ECO:0000255|HAMAP-
CC Rule:MF_00490}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017221; AAS81415.1; -; Genomic_DNA.
DR RefSeq; WP_011173489.1; NC_005835.1.
DR AlphaFoldDB; Q72IQ9; -.
DR SMR; Q72IQ9; -.
DR STRING; 262724.TT_C1073; -.
DR EnsemblBacteria; AAS81415; AAS81415; TT_C1073.
DR KEGG; tth:TT_C1073; -.
DR eggNOG; COG2045; Bacteria.
DR HOGENOM; CLU_070028_0_0_0; -.
DR OMA; RLFMSTT; -.
DR OrthoDB; 1617556at2; -.
DR Proteomes; UP000000592; Chromosome.
DR GO; GO:0050532; F:2-phosphosulfolactate phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.1560.10; -; 1.
DR HAMAP; MF_00490; ComB; 1.
DR InterPro; IPR005238; ComB-like.
DR InterPro; IPR036702; ComB-like_sf.
DR PANTHER; PTHR37311; PTHR37311; 1.
DR Pfam; PF04029; 2-ph_phosp; 1.
DR SUPFAM; SSF142823; SSF142823; 1.
PE 3: Inferred from homology;
KW Hydrolase; Magnesium.
FT CHAIN 1..237
FT /note="Probable 2-phosphosulfolactate phosphatase"
FT /id="PRO_0000081478"
SQ SEQUENCE 237 AA; 24768 MW; 94DE8619E5C9A6BE CRC64;
MRLRVDVIPG EHLAYPDVVL VVDVIRATTT AAAFLEAGAE ALYWTPSLES ALAFKDEDVV
LAGETGGLKP PRFDLGNSPR EALSAQVAGR VVVMSTTNGT KAAHAAARTA KHVLLASLYN
AHAAARLARE LATEEVAILC AGKEGRAGLD DLYTAGVLAE YLGFLGEVEP EDGARVALAV
KRAYPDPLEA LSLSAAALAL KQVGLEADVP FCAQVAKSTA VPVLRGRVGE ALIFKRA
