ID   COMC_METTH              Reviewed;         341 AA.
AC   O27273;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=L-sulfolactate dehydrogenase;
DE            EC=1.1.1.337;
DE   AltName: Full=(R)-sulfolactate dehydrogenase;
DE   AltName: Full=L-2-hydroxycarboxylate dehydrogenase (NAD(+));
GN   Name=comC; OrderedLocusNames=MTH_1205;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate.
CC       Involved in the biosynthesis of both coenzyme M (with (R)-sulfolactate)
CC       and methanopterin (with alpha-ketoglutarate) (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (2S)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate +
CC         H(+) + NADH; Xref=Rhea:RHEA:34555, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:35179, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:58123; EC=1.1.1.337;
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme M biosynthesis;
CC       sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 3/4.
CC   -!- PATHWAY: Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin
CC       biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LDH2/MDH2 oxidoreductase family.
CC       {ECO:0000305}.
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DR   EMBL; AE000666; AAB85694.1; -; Genomic_DNA.
DR   PIR; H69027; H69027.
DR   RefSeq; WP_010876829.1; NC_000916.1.
DR   AlphaFoldDB; O27273; -.
DR   SMR; O27273; -.
DR   STRING; 187420.MTH_1205; -.
DR   EnsemblBacteria; AAB85694; AAB85694; MTH_1205.
DR   GeneID; 1471613; -.
DR   KEGG; mth:MTH_1205; -.
DR   PATRIC; fig|187420.15.peg.1183; -.
DR   HOGENOM; CLU_040452_3_1_2; -.
DR   OMA; TNTEPAM; -.
DR   UniPathway; UPA00065; -.
DR   UniPathway; UPA00355; UER00471.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0102443; F:L-2-hydroxycarboxylate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0019295; P:coenzyme M biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1530.10; -; 1.
DR   Gene3D; 3.30.1370.60; -; 1.
DR   InterPro; IPR043144; Mal/L-sulf/L-lact_DH-like_ah.
DR   InterPro; IPR043143; Mal/L-sulf/L-lact_DH-like_NADP.
DR   InterPro; IPR036111; Mal/L-sulfo/L-lacto_DH-like_sf.
DR   InterPro; IPR003767; Malate/L-lactate_DH-like.
DR   PANTHER; PTHR11091; PTHR11091; 1.
DR   Pfam; PF02615; Ldh_2; 1.
DR   SUPFAM; SSF89733; SSF89733; 1.
PE   3: Inferred from homology;
KW   Coenzyme M biosynthesis; Cytoplasm; NAD; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..341
FT                   /note="L-sulfolactate dehydrogenase"
FT                   /id="PRO_0000083825"
SQ   SEQUENCE   341 AA;  36631 MW;  AC266E12401A1184 CRC64;
     MRISPEEEVK IIKEILTAMN VPEESSDIVA DVTLDADLKG FSSHGIGRFP QYVDGLRHGT
     IRADGDITIE RETESTALIN GNHIFGHVVA YRAMELAIEK ARNTGVGLVG VHDSNHFGVA
     GYYSDMAVMN DMIGVVIANT EPAVAPIGGR KPILGTNPVA IGIPSNRYYV SVDMATSASA
     RGKLLEAARK GESIPENVAL DAEGKPTTDP EMALKGSILP FGGHKGYALS FMIEILAGPL
     VGAAFGTAVT GTANPEEMCT KGDLMMAIDP SKMVDPDEFR AQVDEFIEEV KSSGDVLIPG
     DIESMNIKRR RAEGIELDEK LLERILGIAR ELDINLEIKE L