COMD2_MOUSE
ID COMD2_MOUSE Reviewed; 199 AA.
AC Q8BXC6; Q8BJI3;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=COMM domain-containing protein 2;
GN Name=Commd2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Spinal ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP PROTEIN SEQUENCE OF 38-50, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC (CRL) complexes. May down-regulate activation of NF-kappa-B.
CC {ECO:0000250|UniProtKB:Q86X83}.
CC -!- SUBUNIT: Interacts (via COMM domain) with COMMD1 (via COMM domain).
CC Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with
CC CCDC22, CCDC93, SCNN1B, CUL3, CUL4B, CUL5, CUL7.
CC {ECO:0000250|UniProtKB:Q86X83}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86X83}.
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DR EMBL; AK047941; BAC33194.1; -; mRNA.
DR EMBL; AK083784; BAC39018.1; -; mRNA.
DR CCDS; CCDS17362.1; -.
DR RefSeq; NP_780304.2; NM_175095.4.
DR AlphaFoldDB; Q8BXC6; -.
DR SMR; Q8BXC6; -.
DR BioGRID; 206474; 1.
DR STRING; 10090.ENSMUSP00000124819; -.
DR iPTMnet; Q8BXC6; -.
DR PhosphoSitePlus; Q8BXC6; -.
DR EPD; Q8BXC6; -.
DR MaxQB; Q8BXC6; -.
DR PaxDb; Q8BXC6; -.
DR PRIDE; Q8BXC6; -.
DR ProteomicsDB; 283346; -.
DR Antibodypedia; 48056; 54 antibodies from 15 providers.
DR DNASU; 52245; -.
DR Ensembl; ENSMUST00000160959; ENSMUSP00000124819; ENSMUSG00000036513.
DR GeneID; 52245; -.
DR KEGG; mmu:52245; -.
DR UCSC; uc008phd.1; mouse.
DR CTD; 51122; -.
DR MGI; MGI:1098806; Commd2.
DR VEuPathDB; HostDB:ENSMUSG00000036513; -.
DR eggNOG; ENOG502QU0W; Eukaryota.
DR GeneTree; ENSGT00390000008489; -.
DR HOGENOM; CLU_096212_1_0_1; -.
DR InParanoid; Q8BXC6; -.
DR OMA; RNLEWRI; -.
DR OrthoDB; 1458356at2759; -.
DR PhylomeDB; Q8BXC6; -.
DR TreeFam; TF323519; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR BioGRID-ORCS; 52245; 7 hits in 71 CRISPR screens.
DR PRO; PR:Q8BXC6; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q8BXC6; protein.
DR Bgee; ENSMUSG00000036513; Expressed in animal zygote and 260 other tissues.
DR ExpressionAtlas; Q8BXC6; baseline and differential.
DR Genevisible; Q8BXC6; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd04750; Commd2; 1.
DR InterPro; IPR017920; COMM.
DR InterPro; IPR037354; Commd2.
DR PANTHER; PTHR15857; PTHR15857; 1.
DR Pfam; PF07258; COMM_domain; 1.
DR PROSITE; PS51269; COMM; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; Reference proteome; Transcription;
KW Transcription regulation; Ubl conjugation pathway.
FT CHAIN 1..199
FT /note="COMM domain-containing protein 2"
FT /id="PRO_0000077387"
FT DOMAIN 123..190
FT /note="COMM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
FT CONFLICT 17
FT /note="P -> A (in Ref. 1; BAC39018)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 199 AA; 22848 MW; F569762574608B05 CRC64;
MLLDLSEEHK EHLAFLPQVD TAVVAEFGRI AVEFLRRGSN PKIYEGAARK LNVSSDTIQH
GVEGLTYLLT ESSKLMISEL DFQDSVFVLG FSEELNKLLL QLYLDNRKEI RTILNELAPR
LPSYHSLEWR LDVQLASRSL RQQIKPAVTI KLHLDQNGDH STHFLQTDPA TLLHLVQQLE
QALEEMKTNH CRRVVRSIK
