ID   COMD2_PONAB             Reviewed;         199 AA.
AC   Q5R610;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=COMM domain-containing protein 2;
GN   Name=COMMD2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC       (CRL) complexes. May down-regulate activation of NF-kappa-B.
CC       {ECO:0000250|UniProtKB:Q86X83}.
CC   -!- SUBUNIT: Interacts (via COMM domain) with COMMD1 (via COMM domain).
CC       Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with
CC       CCDC22, CCDC93, SCNN1B, CUL3, CUL4B, CUL5, CUL7.
CC       {ECO:0000250|UniProtKB:Q86X83}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86X83}.
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DR   EMBL; CR860690; CAH92806.1; -; mRNA.
DR   RefSeq; NP_001126637.1; NM_001133165.1.
DR   AlphaFoldDB; Q5R610; -.
DR   SMR; Q5R610; -.
DR   STRING; 9601.ENSPPYP00000015880; -.
DR   Ensembl; ENSPPYT00000016509; ENSPPYP00000015880; ENSPPYG00000014200.
DR   GeneID; 100173635; -.
DR   KEGG; pon:100173635; -.
DR   CTD; 51122; -.
DR   eggNOG; ENOG502QU0W; Eukaryota.
DR   GeneTree; ENSGT00390000008489; -.
DR   InParanoid; Q5R610; -.
DR   OrthoDB; 1458356at2759; -.
DR   Proteomes; UP000001595; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd04750; Commd2; 1.
DR   InterPro; IPR017920; COMM.
DR   InterPro; IPR037354; Commd2.
DR   PANTHER; PTHR15857; PTHR15857; 1.
DR   Pfam; PF07258; COMM_domain; 1.
DR   PROSITE; PS51269; COMM; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Transcription; Transcription regulation;
KW   Ubl conjugation pathway.
FT   CHAIN           1..199
FT                   /note="COMM domain-containing protein 2"
FT                   /id="PRO_0000077388"
FT   DOMAIN          123..190
FT                   /note="COMM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
SQ   SEQUENCE   199 AA;  22805 MW;  87A1C655228E2F1F CRC64;
     MLLELSEEHK EHLAFLPQVD SSVVAEFGRI AVEFLRRGAN PKIYEGAARK LNVSSDTVQH
     GVEGLTYLLT ESSKLMISEL DFQDSVFVLG FSEELNKLLL QLYLDNRKEI RMILSELAPS
     LPSYHNLEWR LDVQLASRSL RQQIKPAVTI KLHLNQNGDH NTKILQTDPA TLLHLVQQLE
     QALEEMKTNH CRRVVRNIK