ID   COMD3_BOVIN             Reviewed;         195 AA.
AC   Q3SZ76;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=COMM domain-containing protein 3;
GN   Name=COMMD3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC       (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates
CC       Na(+) transport in epithelial cells by regulation of apical cell
CC       surface expression of amiloride-sensitive sodium channel (ENaC)
CC       subunits. {ECO:0000250|UniProtKB:Q9UBI1}.
CC   -!- SUBUNIT: Interacts (via COMM domain) with COMMD1 (via COMM domain).
CC       Interacts with NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL3,
CC       CUL4A, CUL4B, CUL5. {ECO:0000250|UniProtKB:Q9UBI1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UBI1}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9UBI1}.
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DR   EMBL; BC103075; AAI03076.1; -; mRNA.
DR   RefSeq; NP_001070467.1; NM_001076999.1.
DR   AlphaFoldDB; Q3SZ76; -.
DR   STRING; 9913.ENSBTAP00000004668; -.
DR   PaxDb; Q3SZ76; -.
DR   PRIDE; Q3SZ76; -.
DR   GeneID; 767926; -.
DR   KEGG; bta:767926; -.
DR   CTD; 23412; -.
DR   eggNOG; ENOG502R79J; Eukaryota.
DR   InParanoid; Q3SZ76; -.
DR   OrthoDB; 1508761at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR017920; COMM.
DR   InterPro; IPR037355; COMMD3.
DR   PANTHER; PTHR31159; PTHR31159; 1.
DR   Pfam; PF07258; COMM_domain; 1.
DR   PROSITE; PS51269; COMM; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Ion transport; Nucleus; Reference proteome; Sodium;
KW   Sodium transport; Transcription; Transcription regulation; Transport;
KW   Ubl conjugation pathway.
FT   CHAIN           1..195
FT                   /note="COMM domain-containing protein 3"
FT                   /id="PRO_0000260182"
FT   DOMAIN          124..193
FT                   /note="COMM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
SQ   SEQUENCE   195 AA;  22310 MW;  7BAD8071EF76E07A CRC64;
     MELSEYVQKG FQMLADPGSF DSNTFTLLLR AAFQSLLDAQ ADEAVLDHPD LKHIDPVVLK
     HRHAAAATYI LEAGKQRADR STLSTYLEDC KFDSERIELF WTEYQNNRNS LEILLGSIGR
     SLPHITDVSW RLEYQIKTNQ LDKMYRPAYL VTLNVENTDS RSHPEISFSC NMEQLQDLVG
     KLKDASKSLE RATQL