COMD3_MOUSE
ID COMD3_MOUSE Reviewed; 195 AA.
AC Q63829; A2ASR4; Q3UKI1; Q8C9P5;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=COMM domain-containing protein 3;
DE AltName: Full=Bmi-1 upstream gene protein;
DE Short=Bup protein;
GN Name=Commd3; Synonyms=Bup;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=1287475; DOI=10.1007/bf01006395;
RA Haupt Y., Barri G., Adams J.M.;
RT "Nucleotide sequence of bup, an upstream gene in the bmi-1 proviral
RT insertion locus.";
RL Mol. Biol. Rep. 17:17-20(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Placenta, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates
CC Na(+) transport in epithelial cells by regulation of apical cell
CC surface expression of amiloride-sensitive sodium channel (ENaC)
CC subunits. {ECO:0000250|UniProtKB:Q9UBI1}.
CC -!- SUBUNIT: Interacts (via COMM domain) with COMMD1 (via COMM domain).
CC Interacts with NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL3,
CC CUL4A, CUL4B, CUL5. {ECO:0000250|UniProtKB:Q9UBI1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UBI1}. Nucleus
CC {ECO:0000250|UniProtKB:Q9UBI1}.
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DR EMBL; S54914; AAB25378.1; -; Unassigned_DNA.
DR EMBL; AK041634; BAC31015.1; -; mRNA.
DR EMBL; AK145955; BAE26783.1; -; mRNA.
DR EMBL; AK145999; BAE26820.1; -; mRNA.
DR EMBL; AL928680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC048815; AAH48815.1; -; mRNA.
DR CCDS; CCDS15710.1; -.
DR RefSeq; NP_680087.1; NM_147778.3.
DR AlphaFoldDB; Q63829; -.
DR SMR; Q63829; -.
DR BioGRID; 198407; 1.
DR STRING; 10090.ENSMUSP00000049882; -.
DR iPTMnet; Q63829; -.
DR PhosphoSitePlus; Q63829; -.
DR EPD; Q63829; -.
DR jPOST; Q63829; -.
DR MaxQB; Q63829; -.
DR PaxDb; Q63829; -.
DR PeptideAtlas; Q63829; -.
DR PRIDE; Q63829; -.
DR ProteomicsDB; 283347; -.
DR Antibodypedia; 25612; 89 antibodies from 17 providers.
DR DNASU; 12238; -.
DR Ensembl; ENSMUST00000061158; ENSMUSP00000049882; ENSMUSG00000051154.
DR Ensembl; ENSMUST00000171845; ENSMUSP00000127385; ENSMUSG00000051154.
DR GeneID; 12238; -.
DR KEGG; mmu:12238; -.
DR UCSC; uc008ilx.1; mouse.
DR CTD; 23412; -.
DR MGI; MGI:88218; Commd3.
DR VEuPathDB; HostDB:ENSMUSG00000051154; -.
DR eggNOG; ENOG502R79J; Eukaryota.
DR GeneTree; ENSGT00390000015971; -.
DR HOGENOM; CLU_118734_0_0_1; -.
DR InParanoid; Q63829; -.
DR OMA; HIVDIDW; -.
DR OrthoDB; 1508761at2759; -.
DR PhylomeDB; Q63829; -.
DR TreeFam; TF329267; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR Reactome; R-MMU-8951664; Neddylation.
DR BioGRID-ORCS; 12238; 15 hits in 75 CRISPR screens.
DR ChiTaRS; Commd3; mouse.
DR PRO; PR:Q63829; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q63829; protein.
DR Bgee; ENSMUSG00000051154; Expressed in cortical plate and 233 other tissues.
DR Genevisible; Q63829; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR017920; COMM.
DR InterPro; IPR037355; COMMD3.
DR PANTHER; PTHR31159; PTHR31159; 1.
DR Pfam; PF07258; COMM_domain; 1.
DR PROSITE; PS51269; COMM; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Ion transport; Nucleus; Reference proteome; Sodium;
KW Sodium transport; Transcription; Transcription regulation; Transport;
KW Ubl conjugation pathway.
FT CHAIN 1..195
FT /note="COMM domain-containing protein 3"
FT /id="PRO_0000077390"
FT DOMAIN 124..193
FT /note="COMM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
SQ SEQUENCE 195 AA; 22037 MW; 7F7A3ACB43699D6D CRC64;
MELSESVQRG IQTLADPGSF DSNAFALLLR AAFQSLLDAR ADEAALDHPY LKQIDPVVLK
HCHAAAATCI LEAGKHQVDK STLSTYLEDC KFDRERIELF CTEYQNNKNS LETLLGSIGR
SLPHITDVSW RLEYQIKTNQ LHKMYRPGYL VTLNVENNDS QSYPEINFSC NMEQLQDLVG
KLKDASKSLE RATQL
