ID   COMD3_RAT               Reviewed;         195 AA.
AC   Q6P9U3;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=COMM domain-containing protein 3;
GN   Name=Commd3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=23637203; DOI=10.1152/ajprenal.00158.2013;
RA   Liu Y.F., Swart M., Ke Y., Ly K., McDonald F.J.;
RT   "Functional interaction of COMMD3 and COMMD9 with the epithelial sodium
RT   channel.";
RL   Am. J. Physiol. 305:F80-F89(2013).
CC   -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC       (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates
CC       Na(+) transport in epithelial cells by regulation of apical cell
CC       surface expression of amiloride-sensitive sodium channel (ENaC)
CC       subunits. {ECO:0000250|UniProtKB:Q9UBI1}.
CC   -!- SUBUNIT: Interacts (via COMM domain) with COMMD1 (via COMM domain).
CC       Interacts with NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL3,
CC       CUL4A, CUL4B, CUL5. {ECO:0000250|UniProtKB:Q9UBI1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23637203}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9UBI1}.
CC   -!- TISSUE SPECIFICITY: Expressed in kidney collecting duct cells and in
CC       the nuclei of proximal convoluted tubule cells in the kidney cortex (at
CC       protein level). {ECO:0000269|PubMed:23637203}.
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DR   EMBL; BC060591; AAH60591.1; -; mRNA.
DR   RefSeq; NP_942027.1; NM_198732.2.
DR   AlphaFoldDB; Q6P9U3; -.
DR   SMR; Q6P9U3; -.
DR   IntAct; Q6P9U3; 2.
DR   STRING; 10116.ENSRNOP00000022201; -.
DR   iPTMnet; Q6P9U3; -.
DR   PhosphoSitePlus; Q6P9U3; -.
DR   jPOST; Q6P9U3; -.
DR   PaxDb; Q6P9U3; -.
DR   PRIDE; Q6P9U3; -.
DR   Ensembl; ENSRNOT00000022201; ENSRNOP00000022201; ENSRNOG00000016383.
DR   GeneID; 291339; -.
DR   KEGG; rno:291339; -.
DR   UCSC; RGD:735116; rat.
DR   CTD; 23412; -.
DR   RGD; 735116; Commd3.
DR   eggNOG; ENOG502R79J; Eukaryota.
DR   GeneTree; ENSGT00390000015971; -.
DR   HOGENOM; CLU_118734_0_0_1; -.
DR   InParanoid; Q6P9U3; -.
DR   OMA; HIVDIDW; -.
DR   OrthoDB; 1508761at2759; -.
DR   PhylomeDB; Q6P9U3; -.
DR   Reactome; R-RNO-6798695; Neutrophil degranulation.
DR   Reactome; R-RNO-8951664; Neddylation.
DR   PRO; PR:Q6P9U3; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   Bgee; ENSRNOG00000016383; Expressed in cerebellum and 20 other tissues.
DR   Genevisible; Q6P9U3; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR017920; COMM.
DR   InterPro; IPR037355; COMMD3.
DR   PANTHER; PTHR31159; PTHR31159; 1.
DR   Pfam; PF07258; COMM_domain; 1.
DR   PROSITE; PS51269; COMM; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Ion transport; Nucleus; Reference proteome; Sodium;
KW   Sodium transport; Transcription; Transcription regulation; Transport;
KW   Ubl conjugation pathway.
FT   CHAIN           1..195
FT                   /note="COMM domain-containing protein 3"
FT                   /id="PRO_0000077391"
FT   DOMAIN          124..193
FT                   /note="COMM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
SQ   SEQUENCE   195 AA;  21932 MW;  1DE015BC9312BB86 CRC64;
     MELSEYVQRG IQTLADPGSF DSSAFALLLR AAFQSLLDAQ ADEAALDHPD LKHIDPVVLK
     HCHGAAATYI LEAGKHRVDK STLSTYLEDC KFDRERIELF CTEYQNNKNS LEILLGSIGR
     ALPHITDVSW RLEYQIKTNQ LHKMCRPGYL VTLNVENADS QSYPEISFSC SMEQLQDLVG
     KLKDASKSLE RATQL