COMD4_BOVIN
ID COMD4_BOVIN Reviewed; 199 AA.
AC Q5E9V6; Q0II55; Q5E9J0; Q5E9V9;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=COMM domain-containing protein 4;
GN Name=COMMD4;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC (CRL) complexes. Down-regulates activation of NF-kappa-B.
CC {ECO:0000250|UniProtKB:Q9H0A8}.
CC -!- SUBUNIT: Interacts (via COMM domain) with COMMD1 (via COMM domain).
CC Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93,
CC SCNN1B, CUL2, CUL3, CUL4A, CUL5, CUL7. {ECO:0000250|UniProtKB:Q9H0A8}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H0A8}. Nucleus
CC {ECO:0000250|UniProtKB:Q9H0A8}.
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DR EMBL; BT020731; AAX08748.1; -; mRNA.
DR EMBL; BT020811; AAX08828.1; -; mRNA.
DR EMBL; BT020814; AAX08831.1; -; mRNA.
DR EMBL; BT020820; AAX08837.1; -; mRNA.
DR EMBL; BT020878; AAX08895.1; -; mRNA.
DR EMBL; BT020882; AAX08899.1; -; mRNA.
DR EMBL; BT020897; AAX08914.1; -; mRNA.
DR EMBL; BT020914; AAX08931.1; -; mRNA.
DR EMBL; BT020930; AAX08947.1; -; mRNA.
DR EMBL; BT020940; AAX08957.1; -; mRNA.
DR EMBL; BT021894; AAX46741.1; -; mRNA.
DR EMBL; BC122799; AAI22800.1; -; mRNA.
DR RefSeq; NP_001035687.1; NM_001040597.1.
DR AlphaFoldDB; Q5E9V6; -.
DR SMR; Q5E9V6; -.
DR STRING; 9913.ENSBTAP00000009665; -.
DR PaxDb; Q5E9V6; -.
DR PRIDE; Q5E9V6; -.
DR Ensembl; ENSBTAT00000009665; ENSBTAP00000009665; ENSBTAG00000007346.
DR Ensembl; ENSBTAT00000029872; ENSBTAP00000029868; ENSBTAG00000007346.
DR GeneID; 616960; -.
DR KEGG; bta:616960; -.
DR CTD; 54939; -.
DR VEuPathDB; HostDB:ENSBTAG00000007346; -.
DR VGNC; VGNC:27585; COMMD4.
DR eggNOG; ENOG502QSP3; Eukaryota.
DR GeneTree; ENSGT00390000015516; -.
DR HOGENOM; CLU_095496_0_0_1; -.
DR InParanoid; Q5E9V6; -.
DR OMA; TAVACIN; -.
DR OrthoDB; 1505629at2759; -.
DR TreeFam; TF317482; -.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000007346; Expressed in retina and 108 other tissues.
DR ExpressionAtlas; Q5E9V6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd04752; Commd4; 1.
DR InterPro; IPR017920; COMM.
DR InterPro; IPR037356; Commd4.
DR Pfam; PF07258; COMM_domain; 1.
DR PROSITE; PS51269; COMM; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Ubl conjugation pathway.
FT CHAIN 1..199
FT /note="COMM domain-containing protein 4"
FT /id="PRO_0000077392"
FT DOMAIN 130..199
FT /note="COMM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
FT CONFLICT 152
FT /note="E -> D (in Ref. 1; AAX08947)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 199 AA; 21648 MW; 427FC209B5D0C215 CRC64;
MRFRFCGDLD CPDWVLAEIS TLAKISSVKL RLLCGQVLKD LLGGGIDYEK ILKLTMDARF
ESGDVKATVA VLSFILSSAA KHSVDGESLS SELQQLGLPK EHAASLCRCY EEKQSSLQAR
LRACSLRVNR LVGVGWRVDY TLSSSLLRTV EEPLVHLRLE VAASPGAPAQ PVAMSLSADK
FQVLLADLKQ AQTLMSNVG
