COMD4_MOUSE
ID COMD4_MOUSE Reviewed; 199 AA.
AC Q9CQ02;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=COMM domain-containing protein 4;
GN Name=Commd4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC (CRL) complexes. Down-regulates activation of NF-kappa-B.
CC {ECO:0000250|UniProtKB:Q9H0A8}.
CC -!- SUBUNIT: Interacts (via COMM domain) with COMMD1 (via COMM domain).
CC Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93,
CC SCNN1B, CUL2, CUL3, CUL4A, CUL5, CUL7. {ECO:0000250|UniProtKB:Q9H0A8}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H0A8}. Nucleus
CC {ECO:0000250|UniProtKB:Q9H0A8}.
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DR EMBL; AK009802; BAB26512.1; -; mRNA.
DR EMBL; AK004174; BAB23207.1; -; mRNA.
DR EMBL; BC033438; AAH33438.1; -; mRNA.
DR EMBL; BC049222; AAH49222.1; -; mRNA.
DR CCDS; CCDS40647.1; -.
DR RefSeq; NP_079693.1; NM_025417.2.
DR AlphaFoldDB; Q9CQ02; -.
DR SMR; Q9CQ02; -.
DR BioGRID; 211291; 3.
DR STRING; 10090.ENSMUSP00000069078; -.
DR iPTMnet; Q9CQ02; -.
DR PhosphoSitePlus; Q9CQ02; -.
DR EPD; Q9CQ02; -.
DR jPOST; Q9CQ02; -.
DR MaxQB; Q9CQ02; -.
DR PaxDb; Q9CQ02; -.
DR PeptideAtlas; Q9CQ02; -.
DR PRIDE; Q9CQ02; -.
DR ProteomicsDB; 283603; -.
DR Antibodypedia; 55565; 102 antibodies from 17 providers.
DR DNASU; 66199; -.
DR Ensembl; ENSMUST00000065358; ENSMUSP00000069078; ENSMUSG00000032299.
DR GeneID; 66199; -.
DR KEGG; mmu:66199; -.
DR UCSC; uc009pul.1; mouse.
DR CTD; 54939; -.
DR MGI; MGI:1913449; Commd4.
DR VEuPathDB; HostDB:ENSMUSG00000032299; -.
DR eggNOG; ENOG502QSP3; Eukaryota.
DR GeneTree; ENSGT00390000015516; -.
DR HOGENOM; CLU_095496_0_0_1; -.
DR InParanoid; Q9CQ02; -.
DR OMA; TAVACIN; -.
DR OrthoDB; 1505629at2759; -.
DR PhylomeDB; Q9CQ02; -.
DR TreeFam; TF317482; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR BioGRID-ORCS; 66199; 8 hits in 74 CRISPR screens.
DR ChiTaRS; Commd4; mouse.
DR PRO; PR:Q9CQ02; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9CQ02; protein.
DR Bgee; ENSMUSG00000032299; Expressed in yolk sac and 268 other tissues.
DR ExpressionAtlas; Q9CQ02; baseline and differential.
DR Genevisible; Q9CQ02; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR CDD; cd04752; Commd4; 1.
DR InterPro; IPR017920; COMM.
DR InterPro; IPR037356; Commd4.
DR Pfam; PF07258; COMM_domain; 1.
DR PROSITE; PS51269; COMM; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Ubl conjugation pathway.
FT CHAIN 1..199
FT /note="COMM domain-containing protein 4"
FT /id="PRO_0000077394"
FT DOMAIN 130..199
FT /note="COMM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
SQ SEQUENCE 199 AA; 21860 MW; E07656167DAEAFA4 CRC64;
MRFRFCGDLD CPDWVLAEIS TLAKISSVKL RLLCSQVLKE LLGQGIDYEK ILKLTADAKF
ESGDVKATVA VLSFILSSAA KHSVDSDSLS SELQQLGLPK EHATSLCRCY EEKQSPLQEH
LRACSLRVNR LASVGWRVDY TLSSSLLHSV EEPMVHLQLQ VVPAPGTQAQ PVSMSLSADK
FQVLLAELKQ AQTMMTALG
