ID   COMD5_BOVIN             Reviewed;         224 AA.
AC   Q5E9K1;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=COMM domain-containing protein 5;
GN   Name=COMMD5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC       (CRL) complexes. Negatively regulates cell proliferation. Negatively
CC       regulates cell cycle G2/M phase transition probably by transactivating
CC       p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved
CC       in kidney proximal tubule morphogenesis. Down-regulates activation of
CC       NF-kappa-B. {ECO:0000250|UniProtKB:Q9ERR2,
CC       ECO:0000250|UniProtKB:Q9GZQ3}.
CC   -!- SUBUNIT: Interacts (via COMM domain) with COMMD1 (via COMM domain).
CC       Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93,
CC       SCNN1B, CUL2, CUL3, CUL4A, CUL4B, CUL7. {ECO:0000250|UniProtKB:Q9GZQ3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9GZQ3}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9GZQ3}.
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DR   EMBL; BT020919; AAX08936.1; -; mRNA.
DR   RefSeq; NP_001014850.1; NM_001014850.1.
DR   RefSeq; XP_005215206.1; XM_005215149.3.
DR   RefSeq; XP_010810125.1; XM_010811823.2.
DR   RefSeq; XP_010810126.1; XM_010811824.2.
DR   RefSeq; XP_015329817.1; XM_015474331.1.
DR   AlphaFoldDB; Q5E9K1; -.
DR   STRING; 9913.ENSBTAP00000024561; -.
DR   PaxDb; Q5E9K1; -.
DR   PRIDE; Q5E9K1; -.
DR   Ensembl; ENSBTAT00000024561; ENSBTAP00000024561; ENSBTAG00000018455.
DR   GeneID; 504807; -.
DR   KEGG; bta:504807; -.
DR   CTD; 28991; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018455; -.
DR   VGNC; VGNC:27586; COMMD5.
DR   eggNOG; ENOG502RCJ6; Eukaryota.
DR   GeneTree; ENSGT00390000013770; -.
DR   HOGENOM; CLU_091901_0_0_1; -.
DR   InParanoid; Q5E9K1; -.
DR   OMA; DCQEAVQ; -.
DR   OrthoDB; 1351388at2759; -.
DR   TreeFam; TF323880; -.
DR   Proteomes; UP000009136; Chromosome 14.
DR   Bgee; ENSBTAG00000018455; Expressed in retina and 109 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   InterPro; IPR017920; COMM.
DR   InterPro; IPR037357; COMMD5.
DR   PANTHER; PTHR15666; PTHR15666; 1.
DR   Pfam; PF07258; COMM_domain; 1.
DR   PROSITE; PS51269; COMM; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Ubl conjugation pathway.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9GZQ3"
FT   CHAIN           2..224
FT                   /note="COMM domain-containing protein 5"
FT                   /id="PRO_0000239238"
FT   DOMAIN          151..215
FT                   /note="COMM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9GZQ3"
SQ   SEQUENCE   224 AA;  24502 MW;  9ADA0380D6E30CDA CRC64;
     MSAVGPAAAH LHRPGDSHSD CVSFLGAQLP PEVAAMPQLL GDLDRATFRK LLKLVVSSLQ
     GEDCREAVQH LRAGANLPEE QLGALIAGTH TLLQQALRLP PASLKPDTFK NQLQELCIPQ
     DLVVDLASVV FGSQRPLLDS VARQQGAWLP HIADFRWRVD VAISTSALAR SLQPSVLMHL
     KLSDGSALRF EVPTAKFQEL RFAVALVLKE MADLEKRCER KLQD