ID   COMD6_BOVIN             Reviewed;          85 AA.
AC   Q2KIY0;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=COMM domain-containing protein 6;
GN   Name=COMMD6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC       (CRL) complexes. Inhibits TNF-induced NFKB1 activation.
CC       {ECO:0000250|UniProtKB:Q7Z4G1}.
CC   -!- SUBUNIT: Homodimer. Interacts (via COMM domain) with COMMD1 (via COMM
CC       domain). Does not interact with NFKBIB. Interacts with RELA, RELB,
CC       NFKB1/p105. Does not interact with NFKBIB. Interacts with CCDC22,
CC       CCDC93, SCNN1B, CUL4A. {ECO:0000250|UniProtKB:Q7Z4G1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7Z4G1}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q7Z4G1}.
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DR   EMBL; BC112466; AAI12467.1; -; mRNA.
DR   RefSeq; NP_001106783.1; NM_001113312.2.
DR   AlphaFoldDB; Q2KIY0; -.
DR   SMR; Q2KIY0; -.
DR   STRING; 9913.ENSBTAP00000055877; -.
DR   PaxDb; Q2KIY0; -.
DR   GeneID; 616226; -.
DR   KEGG; bta:616226; -.
DR   CTD; 170622; -.
DR   eggNOG; ENOG502S1WA; Eukaryota.
DR   InParanoid; Q2KIY0; -.
DR   OrthoDB; 1516873at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051059; F:NF-kappaB binding; IBA:GO_Central.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IBA:GO_Central.
DR   InterPro; IPR017920; COMM.
DR   Pfam; PF07258; COMM_domain; 1.
DR   PROSITE; PS51269; COMM; 1.
PE   3: Inferred from homology;
KW   Acetylation; Cytoplasm; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Ubl conjugation pathway.
FT   CHAIN           1..85
FT                   /note="COMM domain-containing protein 6"
FT                   /id="PRO_0000260183"
FT   DOMAIN          18..85
FT                   /note="COMM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z4G1"
SQ   SEQUENCE   85 AA;  9725 MW;  02EC619FB0272ADF CRC64;
     MEESSEPQLD AKSKVTSQLI DFEWKLGMAV SSDSCRSLKY PYVAVMLKVA DHSGQVKNKS
     FEMTIPQFQN FYRQFKEIAA IIETV