ID   COMD6_MOUSE             Reviewed;          87 AA.
AC   Q3V4B5;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=COMM domain-containing protein 6;
GN   Name=Commd6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Heart, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC       (CRL) complexes. Inhibits TNF-induced NFKB1 activation.
CC       {ECO:0000250|UniProtKB:Q7Z4G1}.
CC   -!- SUBUNIT: Homodimer. Interacts (via COMM domain) with COMMD1 (via COMM
CC       domain). Does not interact with NFKBIB. Interacts with RELA, RELB,
CC       NFKB1/p105. Does not interact with NFKBIB. Interacts with CCDC22,
CC       CCDC93, SCNN1B, CUL4A. {ECO:0000250|UniProtKB:Q7Z4G1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7Z4G1}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q7Z4G1}.
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DR   EMBL; AK004316; BAE43169.1; -; mRNA.
DR   EMBL; BC132261; AAI32262.1; -; mRNA.
DR   EMBL; BC132265; AAI32266.1; -; mRNA.
DR   CCDS; CCDS37000.1; -.
DR   RefSeq; NP_001028304.1; NM_001033132.3.
DR   AlphaFoldDB; Q3V4B5; -.
DR   SMR; Q3V4B5; -.
DR   BioGRID; 211292; 1.
DR   STRING; 10090.ENSMUSP00000097912; -.
DR   iPTMnet; Q3V4B5; -.
DR   PhosphoSitePlus; Q3V4B5; -.
DR   EPD; Q3V4B5; -.
DR   MaxQB; Q3V4B5; -.
DR   PaxDb; Q3V4B5; -.
DR   PRIDE; Q3V4B5; -.
DR   ProteomicsDB; 285246; -.
DR   Antibodypedia; 71333; 29 antibodies from 6 providers.
DR   Ensembl; ENSMUST00000100339; ENSMUSP00000097912; ENSMUSG00000075486.
DR   GeneID; 66200; -.
DR   KEGG; mmu:66200; -.
DR   UCSC; uc007uvt.2; mouse.
DR   CTD; 170622; -.
DR   MGI; MGI:1913450; Commd6.
DR   VEuPathDB; HostDB:ENSMUSG00000075486; -.
DR   eggNOG; ENOG502S1WA; Eukaryota.
DR   GeneTree; ENSGT00390000018369; -.
DR   InParanoid; Q3V4B5; -.
DR   OMA; IADHAGH; -.
DR   OrthoDB; 1516873at2759; -.
DR   PhylomeDB; Q3V4B5; -.
DR   TreeFam; TF333414; -.
DR   Reactome; R-MMU-8951664; Neddylation.
DR   BioGRID-ORCS; 66200; 2 hits in 70 CRISPR screens.
DR   ChiTaRS; Commd6; mouse.
DR   PRO; PR:Q3V4B5; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; Q3V4B5; protein.
DR   Bgee; ENSMUSG00000075486; Expressed in gonadal fat pad and 253 other tissues.
DR   ExpressionAtlas; Q3V4B5; baseline and differential.
DR   Genevisible; Q3V4B5; MM.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051059; F:NF-kappaB binding; ISO:MGI.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISO:MGI.
DR   InterPro; IPR017920; COMM.
DR   Pfam; PF07258; COMM_domain; 1.
DR   PROSITE; PS51269; COMM; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Ubl conjugation pathway.
FT   CHAIN           1..87
FT                   /note="COMM domain-containing protein 6"
FT                   /id="PRO_0000294141"
FT   DOMAIN          20..87
FT                   /note="COMM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z4G1"
SQ   SEQUENCE   87 AA;  9795 MW;  B788F8981FA6C90D CRC64;
     MEESGFREPV LDAKSEVTGQ LIDFQWKLGM AVSSDSCRSL KYPYVAVMLK VADHSGQVSS
     KSIEMTIPQF QNFYKQFKEI AAVIETV