ID   COMD6_XENLA             Reviewed;         197 AA.
AC   Q05AV1;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=COMM domain-containing protein 6;
GN   Name=commd6;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC       (CRL) complexes. Inhibits TNF-induced nfkb1 activation.
CC       {ECO:0000250|UniProtKB:Q7Z4G1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7Z4G1}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q7Z4G1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC123325; AAI23326.1; -; mRNA.
DR   RefSeq; NP_001090390.1; NM_001096921.1.
DR   AlphaFoldDB; Q05AV1; -.
DR   SMR; Q05AV1; -.
DR   DNASU; 779301; -.
DR   GeneID; 779301; -.
DR   KEGG; xla:779301; -.
DR   CTD; 779301; -.
DR   Xenbase; XB-GENE-6252473; commd6.S.
DR   OrthoDB; 1446099at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 779301; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR017920; COMM.
DR   Pfam; PF07258; COMM_domain; 1.
DR   PROSITE; PS51269; COMM; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Ubl conjugation pathway.
FT   CHAIN           1..197
FT                   /note="COMM domain-containing protein 6"
FT                   /id="PRO_0000294142"
FT   DOMAIN          130..197
FT                   /note="COMM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
SQ   SEQUENCE   197 AA;  22473 MW;  AE4E2CF9CC78A870 CRC64;
     MFERELEALG FEKTGDLIKI VPPDLFAELC QQSVQHLQRQ RSGVDCHAIF QSFQAVGVHI
     SEDELRKIIR GMTALFSTAA KYNVTCEELL SMLISKLPKQ ILQVIRHVWN EEGKHLCELQ
     KSRDLLPSGE LVDFHWKIGM AVSSDSCRSL NHPYVTVELK VADYSGQITS KILELTIPEF
     KNFHKQFKEM SAVLETV