ID   COMD6_XENTR             Reviewed;         197 AA.
AC   Q28HC7;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=COMM domain-containing protein 6;
GN   Name=commd6; ORFNames=TEgg014m16.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC       (CRL) complexes. Inhibits TNF-induced nfkb1 activation.
CC       {ECO:0000250|UniProtKB:Q7Z4G1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7Z4G1}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q7Z4G1}.
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DR   EMBL; CR760938; CAJ82026.1; -; mRNA.
DR   RefSeq; NP_001016464.1; NM_001016464.2.
DR   AlphaFoldDB; Q28HC7; -.
DR   SMR; Q28HC7; -.
DR   STRING; 8364.ENSXETP00000010225; -.
DR   PaxDb; Q28HC7; -.
DR   GeneID; 549218; -.
DR   KEGG; xtr:549218; -.
DR   CTD; 170622; -.
DR   Xenbase; XB-GENE-963717; commd6.
DR   eggNOG; ENOG502S0MA; Eukaryota.
DR   InParanoid; Q28HC7; -.
DR   OrthoDB; 1446099at2759; -.
DR   Reactome; R-XTR-8951664; Neddylation.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051059; F:NF-kappaB binding; IBA:GO_Central.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IBA:GO_Central.
DR   InterPro; IPR017920; COMM.
DR   Pfam; PF07258; COMM_domain; 1.
DR   PROSITE; PS51269; COMM; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Ubl conjugation pathway.
FT   CHAIN           1..197
FT                   /note="COMM domain-containing protein 6"
FT                   /id="PRO_0000294143"
FT   DOMAIN          130..197
FT                   /note="COMM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
SQ   SEQUENCE   197 AA;  22681 MW;  7ECE452910A836B8 CRC64;
     MFDRELEAFG FEKTDDLIKI VPPDLFAELC QQSVQHLQRQ RSGVDCQVIF QSFQAAGVLI
     SEDELRKIIR WITTLFSTAA KYNVTCEELL SRLISKLPKQ ILQVIRHVWN EEGKRLSELE
     KSRDLLPSGE LVDFQWKIGM AVSSDSCRSL NHPYVTIELK VADYSGQITS KVFELTIPEF
     QNFHKQVKEM SSVLETV