ID   COMD7_BOVIN             Reviewed;         200 AA.
AC   Q3MHX1;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=COMM domain-containing protein 7;
GN   Name=COMMD7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC       (CRL) complexes. Associates with the NF-kappa-B complex and suppresses
CC       its transcriptional activity. {ECO:0000250|UniProtKB:Q86VX2}.
CC   -!- SUBUNIT: Interacts (via COMM domain) with COMMD1 (via COMM domain).
CC       Interacts with RELA. Interacts with CCDC22, CCDC93, SCNN1B, CUL7.
CC       {ECO:0000250|UniProtKB:Q86VX2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle
CC       {ECO:0000250|UniProtKB:Q86VX2}.
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DR   EMBL; BC104576; AAI04577.1; -; mRNA.
DR   RefSeq; NP_001030368.1; NM_001035291.1.
DR   AlphaFoldDB; Q3MHX1; -.
DR   STRING; 9913.ENSBTAP00000021846; -.
DR   PaxDb; Q3MHX1; -.
DR   PRIDE; Q3MHX1; -.
DR   Ensembl; ENSBTAT00000021846; ENSBTAP00000021846; ENSBTAG00000016427.
DR   GeneID; 514295; -.
DR   KEGG; bta:514295; -.
DR   CTD; 149951; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016427; -.
DR   VGNC; VGNC:27587; COMMD7.
DR   eggNOG; ENOG502QQ17; Eukaryota.
DR   GeneTree; ENSGT00390000012419; -.
DR   HOGENOM; CLU_118172_0_0_1; -.
DR   InParanoid; Q3MHX1; -.
DR   OMA; SQMENVY; -.
DR   OrthoDB; 1553822at2759; -.
DR   TreeFam; TF329046; -.
DR   Proteomes; UP000009136; Chromosome 13.
DR   Bgee; ENSBTAG00000016427; Expressed in thyroid gland and 107 other tissues.
DR   ExpressionAtlas; Q3MHX1; baseline.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0051059; F:NF-kappaB binding; IBA:GO_Central.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IBA:GO_Central.
DR   CDD; cd04755; Commd7; 1.
DR   InterPro; IPR017920; COMM.
DR   InterPro; IPR037358; COMMD7.
DR   Pfam; PF07258; COMM_domain; 1.
DR   PROSITE; PS51269; COMM; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Reference proteome; Transcription;
KW   Transcription regulation; Ubl conjugation pathway.
FT   CHAIN           1..200
FT                   /note="COMM domain-containing protein 7"
FT                   /id="PRO_0000260184"
FT   DOMAIN          133..200
FT                   /note="COMM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
SQ   SEQUENCE   200 AA;  22534 MW;  E8AD4C7675212F18 CRC64;
     MGRLHCTQDP VPEAVGGDMQ QLNQLSAQQF SALTEVLFHF LTEPKEVERF LAQLSEFAAT
     NQISLGPLRS IVKSLLLVPN GALKKGLTAE QVRADFMTLG LSEEKAIYFS EKWKQNAPTL
     ARWAVGQTLM INQLVDMEWK FGVTSGSSEL EKVGSIFLQL KLVVKKGNQT ENVYIELTLP
     QFYSFLHEME RVRTSMECFS