ID   COMD7_MOUSE             Reviewed;         200 AA.
AC   Q8BG94; Q99J75;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=COMM domain-containing protein 7;
GN   Name=Commd7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis, and Tongue;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=129; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC       (CRL) complexes. Associates with the NF-kappa-B complex and suppresses
CC       its transcriptional activity. {ECO:0000250|UniProtKB:Q86VX2}.
CC   -!- SUBUNIT: Interacts (via COMM domain) with COMMD1 (via COMM domain).
CC       Interacts with RELA. Interacts with CCDC22, CCDC93, SCNN1B, CUL7.
CC       {ECO:0000250|UniProtKB:Q86VX2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle
CC       {ECO:0000250|UniProtKB:Q86VX2}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH03310.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK009274; BAC25249.1; -; mRNA.
DR   EMBL; AK078774; BAC37387.1; -; mRNA.
DR   EMBL; BC003310; AAH03310.1; ALT_INIT; mRNA.
DR   CCDS; CCDS16912.2; -.
DR   RefSeq; NP_001182319.1; NM_001195390.1.
DR   RefSeq; NP_598611.2; NM_133850.2.
DR   AlphaFoldDB; Q8BG94; -.
DR   SMR; Q8BG94; -.
DR   BioGRID; 221226; 5.
DR   STRING; 10090.ENSMUSP00000071752; -.
DR   PhosphoSitePlus; Q8BG94; -.
DR   EPD; Q8BG94; -.
DR   MaxQB; Q8BG94; -.
DR   PaxDb; Q8BG94; -.
DR   PRIDE; Q8BG94; -.
DR   ProteomicsDB; 283427; -.
DR   Antibodypedia; 25401; 105 antibodies from 24 providers.
DR   Ensembl; ENSMUST00000071852; ENSMUSP00000071752; ENSMUSG00000056941.
DR   GeneID; 99311; -.
DR   KEGG; mmu:99311; -.
DR   UCSC; uc008nhx.2; mouse.
DR   CTD; 149951; -.
DR   MGI; MGI:1914197; Commd7.
DR   VEuPathDB; HostDB:ENSMUSG00000056941; -.
DR   eggNOG; ENOG502QQ17; Eukaryota.
DR   GeneTree; ENSGT00390000012419; -.
DR   HOGENOM; CLU_118172_0_0_1; -.
DR   InParanoid; Q8BG94; -.
DR   OMA; SQMENVY; -.
DR   OrthoDB; 1553822at2759; -.
DR   PhylomeDB; Q8BG94; -.
DR   Reactome; R-MMU-8951664; Neddylation.
DR   BioGRID-ORCS; 99311; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Commd7; mouse.
DR   PRO; PR:Q8BG94; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q8BG94; protein.
DR   Bgee; ENSMUSG00000056941; Expressed in cortical plate and 256 other tissues.
DR   ExpressionAtlas; Q8BG94; baseline and differential.
DR   Genevisible; Q8BG94; MM.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0051059; F:NF-kappaB binding; ISO:MGI.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISO:MGI.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
DR   GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; ISO:MGI.
DR   CDD; cd04755; Commd7; 1.
DR   InterPro; IPR017920; COMM.
DR   InterPro; IPR037358; COMMD7.
DR   Pfam; PF07258; COMM_domain; 1.
DR   PROSITE; PS51269; COMM; 1.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Reference proteome; Transcription;
KW   Transcription regulation; Ubl conjugation pathway.
FT   CHAIN           1..200
FT                   /note="COMM domain-containing protein 7"
FT                   /id="PRO_0000077400"
FT   DOMAIN          133..200
FT                   /note="COMM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
SQ   SEQUENCE   200 AA;  22652 MW;  B3A4B93DE045B78E CRC64;
     MGRLHCTQDP VPEAVRGDMQ QLNQLGAQQF SDLTEVLFHF LTEPKEVERF LAQLSEFATS
     NQISLGPLKS IMKSLLLVPN GALKKGLTAE QVRTDLQTLG LSEEKATYFS EKWKQNASTL
     AQWAMGQTLM VNQLIDMEWR FGVTSGSSEL EKVGSIFLQL KLVVKKGKQT ENLYMELTLP
     QFYSFLHEME RVRASMECLS