COMD8_MOUSE
ID COMD8_MOUSE Reviewed; 183 AA.
AC Q9CZG3; Q9D7F6;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=COMM domain-containing protein 8;
GN Name=Commd8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC (CRL) complexes. May down-regulate activation of NF-kappa-B.
CC {ECO:0000250|UniProtKB:Q9NX08}.
CC -!- SUBUNIT: Interacts (via COMM domain) with COMMD1 (via COMM domain).
CC Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93,
CC SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5.
CC {ECO:0000250|UniProtKB:Q9NX08}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NX08}. Nucleus
CC {ECO:0000250|UniProtKB:Q9NX08}.
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DR EMBL; AK009275; BAB26187.1; -; mRNA.
DR EMBL; AK012653; BAB28384.1; -; mRNA.
DR EMBL; AK077934; BAC37073.1; -; mRNA.
DR CCDS; CCDS39108.1; -.
DR RefSeq; NP_848714.1; NM_178599.4.
DR AlphaFoldDB; Q9CZG3; -.
DR SMR; Q9CZG3; -.
DR BioGRID; 205530; 5.
DR IntAct; Q9CZG3; 1.
DR MINT; Q9CZG3; -.
DR STRING; 10090.ENSMUSP00000013693; -.
DR PhosphoSitePlus; Q9CZG3; -.
DR EPD; Q9CZG3; -.
DR MaxQB; Q9CZG3; -.
DR PaxDb; Q9CZG3; -.
DR PRIDE; Q9CZG3; -.
DR ProteomicsDB; 283348; -.
DR Antibodypedia; 23755; 91 antibodies from 17 providers.
DR DNASU; 27784; -.
DR Ensembl; ENSMUST00000013693; ENSMUSP00000013693; ENSMUSG00000029213.
DR GeneID; 27784; -.
DR KEGG; mmu:27784; -.
DR UCSC; uc008xre.1; mouse.
DR CTD; 54951; -.
DR MGI; MGI:1343485; Commd8.
DR VEuPathDB; HostDB:ENSMUSG00000029213; -.
DR eggNOG; ENOG502S00F; Eukaryota.
DR GeneTree; ENSGT00390000018121; -.
DR HOGENOM; CLU_116006_0_0_1; -.
DR InParanoid; Q9CZG3; -.
DR OMA; KLCHRVV; -.
DR OrthoDB; 1555523at2759; -.
DR PhylomeDB; Q9CZG3; -.
DR TreeFam; TF328403; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR BioGRID-ORCS; 27784; 5 hits in 74 CRISPR screens.
DR ChiTaRS; Commd8; mouse.
DR PRO; PR:Q9CZG3; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9CZG3; protein.
DR Bgee; ENSMUSG00000029213; Expressed in ear vesicle and 235 other tissues.
DR ExpressionAtlas; Q9CZG3; baseline and differential.
DR Genevisible; Q9CZG3; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR017920; COMM.
DR Pfam; PF07258; COMM_domain; 1.
DR PROSITE; PS51269; COMM; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Ubl conjugation pathway.
FT CHAIN 1..183
FT /note="COMM domain-containing protein 8"
FT /id="PRO_0000077402"
FT DOMAIN 116..183
FT /note="COMM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
FT CONFLICT 29
FT /note="D -> G (in Ref. 1; BAB26187)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 183 AA; 20852 MW; 3FFEC326E080BA2C CRC64;
MEPEEGTPLW RLQKLPPEQG AGLLHKIIDG FCGRAYPAHQ DYHSVWNSAE WKHVLEDVTT
FFKAVVGKNF SEEETLQQLN QLNSCHQEAV LKCLKSRRNE IKQALLGEIV DISCAQLQDF
DWQLKLALSS DKIATLQMPL LNLHLDVKED DKVKPYTVEM SKEELQSLIS SLEAANKVVL
QLK
