ID   COMD9_BOVIN             Reviewed;         198 AA.
AC   Q2TBN5;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=COMM domain-containing protein 9;
GN   Name=COMMD9;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC       (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates
CC       Na(+) transport in epithelial cells by regulation of apical cell
CC       surface expression of amiloride-sensitive sodium channel (ENaC)
CC       subunits. {ECO:0000250|UniProtKB:Q9P000}.
CC   -!- SUBUNIT: Interacts with RELB and NFKB1/p105. Interacts with CCDC22,
CC       CCDC93, SCNN1B, CUL1. {ECO:0000250|UniProtKB:Q9P000}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9P000}.
CC       Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9P000}.
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DR   EMBL; BC109885; AAI09886.1; -; mRNA.
DR   RefSeq; NP_001033609.1; NM_001038520.2.
DR   AlphaFoldDB; Q2TBN5; -.
DR   SMR; Q2TBN5; -.
DR   STRING; 9913.ENSBTAP00000025346; -.
DR   PaxDb; Q2TBN5; -.
DR   GeneID; 510280; -.
DR   KEGG; bta:510280; -.
DR   CTD; 29099; -.
DR   eggNOG; ENOG502RHPY; Eukaryota.
DR   InParanoid; Q2TBN5; -.
DR   OrthoDB; 1452665at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR017920; COMM.
DR   InterPro; IPR037360; COMMD9.
DR   PANTHER; PTHR15663; PTHR15663; 1.
DR   Pfam; PF07258; COMM_domain; 1.
DR   PROSITE; PS51269; COMM; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasmic vesicle; Ion transport; Nucleus;
KW   Reference proteome; Sodium; Sodium transport; Transcription;
KW   Transcription regulation; Transport; Ubl conjugation pathway.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P000"
FT   CHAIN           2..198
FT                   /note="COMM domain-containing protein 9"
FT                   /id="PRO_0000260185"
FT   DOMAIN          122..196
FT                   /note="COMM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P000"
SQ   SEQUENCE   198 AA;  21781 MW;  5CC7CCB77EEEFA17 CRC64;
     MAALTAENFA ALQSLLKASS KDVVRQLCQE SFSSSALGSK NLLDVTCSSL SVTQEEAEQL
     LQALHRLTRL AVFRDLSSAE AILALFPENF HQNLKNLLTK IILEHVSAWR AEAQVNQISL
     PRLVDLDWRV DIKTSSDSIS RMAVPTCLLQ MKIQEDPSLC GDRPSVSDVT VELSKETLDT
     MLDGLGRIRD QLSAVASK