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COMD9_MOUSE
ID   COMD9_MOUSE             Reviewed;         198 AA.
AC   Q8K2Q0; Q3U3J2; Q7TNP5; Q811K2; Q9D8V8;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 3.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=COMM domain-containing protein 9;
GN   Name=Commd9;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Pancreas;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, FVB/N, and FVB/N-3;
RC   TISSUE=Brain, Liver, Mammary tumor, and Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC       (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates
CC       Na(+) transport in epithelial cells by regulation of apical cell
CC       surface expression of amiloride-sensitive sodium channel (ENaC)
CC       subunits. {ECO:0000250|UniProtKB:Q9P000}.
CC   -!- SUBUNIT: Interacts with RELB and NFKB1/p105. Interacts with CCDC22,
CC       CCDC93, SCNN1B, CUL1. {ECO:0000250|UniProtKB:Q9P000}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9P000}.
CC       Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9P000}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH30374.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK007640; BAB25155.1; -; mRNA.
DR   EMBL; AK154731; BAE32794.1; -; mRNA.
DR   EMBL; BC030374; AAH30374.1; ALT_INIT; mRNA.
DR   EMBL; BC043684; AAH43684.1; -; mRNA.
DR   EMBL; BC056201; AAH56201.1; -; mRNA.
DR   EMBL; BC060058; AAH60058.1; -; mRNA.
DR   CCDS; CCDS16465.1; -.
DR   RefSeq; NP_083911.1; NM_029635.3.
DR   AlphaFoldDB; Q8K2Q0; -.
DR   SMR; Q8K2Q0; -.
DR   STRING; 10090.ENSMUSP00000028584; -.
DR   iPTMnet; Q8K2Q0; -.
DR   PhosphoSitePlus; Q8K2Q0; -.
DR   EPD; Q8K2Q0; -.
DR   jPOST; Q8K2Q0; -.
DR   MaxQB; Q8K2Q0; -.
DR   PaxDb; Q8K2Q0; -.
DR   PeptideAtlas; Q8K2Q0; -.
DR   PRIDE; Q8K2Q0; -.
DR   ProteomicsDB; 285247; -.
DR   Antibodypedia; 2123; 174 antibodies from 21 providers.
DR   DNASU; 76501; -.
DR   Ensembl; ENSMUST00000028584; ENSMUSP00000028584; ENSMUSG00000027163.
DR   GeneID; 76501; -.
DR   KEGG; mmu:76501; -.
DR   UCSC; uc008lhq.1; mouse.
DR   CTD; 29099; -.
DR   MGI; MGI:1923751; Commd9.
DR   VEuPathDB; HostDB:ENSMUSG00000027163; -.
DR   eggNOG; ENOG502RHPY; Eukaryota.
DR   GeneTree; ENSGT00390000006218; -.
DR   HOGENOM; CLU_118635_0_0_1; -.
DR   InParanoid; Q8K2Q0; -.
DR   OMA; CVQSHRG; -.
DR   OrthoDB; 1452665at2759; -.
DR   PhylomeDB; Q8K2Q0; -.
DR   TreeFam; TF323880; -.
DR   Reactome; R-MMU-6798695; Neutrophil degranulation.
DR   Reactome; R-MMU-8951664; Neddylation.
DR   BioGRID-ORCS; 76501; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Commd9; mouse.
DR   PRO; PR:Q8K2Q0; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q8K2Q0; protein.
DR   Bgee; ENSMUSG00000027163; Expressed in yolk sac and 257 other tissues.
DR   Genevisible; Q8K2Q0; MM.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0042632; P:cholesterol homeostasis; IMP:MGI.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR017920; COMM.
DR   InterPro; IPR037360; COMMD9.
DR   PANTHER; PTHR15663; PTHR15663; 1.
DR   Pfam; PF07258; COMM_domain; 1.
DR   PROSITE; PS51269; COMM; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasmic vesicle; Ion transport; Nucleus;
KW   Reference proteome; Sodium; Sodium transport; Transcription;
KW   Transcription regulation; Transport; Ubl conjugation pathway.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P000"
FT   CHAIN           2..198
FT                   /note="COMM domain-containing protein 9"
FT                   /id="PRO_0000077404"
FT   DOMAIN          122..196
FT                   /note="COMM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P000"
FT   CONFLICT        21..24
FT                   /note="KDVV -> PTRP (in Ref. 2; AAH56201)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   198 AA;  21850 MW;  24796550D76F6724 CRC64;
     MAALTAEHFV ALQSLLKASS KDVVRQLCQE SFSSSCLDSE SLLDKTCSSL SVPQGEAAQL
     LQALHHFTRL VAFRDLSSAE AILALFPENF HQNLKNLLTK IIVEHISTWR AEAQANQISL
     PRLVDLDWRV DIKTSSDNIS RMAVPTCLLQ MKIQEDPSLC GEKPSISAVT MELSKETLDT
     MLDGLGRIRD QLSAVANK
 
 
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