COMDA_MOUSE
ID COMDA_MOUSE Reviewed; 202 AA.
AC Q8JZY2;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=COMM domain-containing protein 10;
DE AltName: Full=Down-regulated in W/WV mouse stomach 2;
DE Short=mDRWMS2;
GN Name=Commd10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Daigo Y., Takayama I., Fujino M.A.;
RT "Isolation and characterization of novel human and mouse genes, which are
RT expressed in the digestive tract.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Lung, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase
CC (CRL) complexes. May down-regulate activation of NF-kappa-B.
CC {ECO:0000250|UniProtKB:Q9Y6G5}.
CC -!- SUBUNIT: Interacts (via COMM domain) with COMMD1 (via COMM domain).
CC Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with
CC CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL7.
CC {ECO:0000250|UniProtKB:Q9Y6G5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y6G5}. Nucleus
CC {ECO:0000250|UniProtKB:Q9Y6G5}.
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DR EMBL; AB052770; BAC53803.1; -; mRNA.
DR EMBL; BC034879; AAH34879.1; -; mRNA.
DR CCDS; CCDS29238.1; -.
DR RefSeq; NP_848464.1; NM_178377.4.
DR AlphaFoldDB; Q8JZY2; -.
DR SMR; Q8JZY2; -.
DR BioGRID; 213459; 7.
DR STRING; 10090.ENSMUSP00000041650; -.
DR iPTMnet; Q8JZY2; -.
DR PhosphoSitePlus; Q8JZY2; -.
DR EPD; Q8JZY2; -.
DR MaxQB; Q8JZY2; -.
DR PaxDb; Q8JZY2; -.
DR PRIDE; Q8JZY2; -.
DR ProteomicsDB; 283349; -.
DR Antibodypedia; 25475; 140 antibodies from 18 providers.
DR DNASU; 69456; -.
DR Ensembl; ENSMUST00000049388; ENSMUSP00000041650; ENSMUSG00000042705.
DR GeneID; 69456; -.
DR KEGG; mmu:69456; -.
DR UCSC; uc008evz.1; mouse.
DR CTD; 51397; -.
DR MGI; MGI:1916706; Commd10.
DR VEuPathDB; HostDB:ENSMUSG00000042705; -.
DR eggNOG; ENOG502QWQ2; Eukaryota.
DR GeneTree; ENSGT00390000001500; -.
DR HOGENOM; CLU_091039_0_0_1; -.
DR InParanoid; Q8JZY2; -.
DR OMA; VEFNHQE; -.
DR OrthoDB; 1549928at2759; -.
DR PhylomeDB; Q8JZY2; -.
DR TreeFam; TF352584; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR BioGRID-ORCS; 69456; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Commd10; mouse.
DR PRO; PR:Q8JZY2; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8JZY2; protein.
DR Bgee; ENSMUSG00000042705; Expressed in manus and 230 other tissues.
DR ExpressionAtlas; Q8JZY2; baseline and differential.
DR Genevisible; Q8JZY2; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR CDD; cd04758; Commd10; 1.
DR InterPro; IPR017920; COMM.
DR InterPro; IPR037361; COMMD10.
DR PANTHER; PTHR12333; PTHR12333; 1.
DR Pfam; PF07258; COMM_domain; 1.
DR PROSITE; PS51269; COMM; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Ubl conjugation pathway.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6G5"
FT CHAIN 2..202
FT /note="COMM domain-containing protein 10"
FT /id="PRO_0000077406"
FT DOMAIN 133..202
FT /note="COMM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00602"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6G5"
FT MOD_RES 155
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6G5"
SQ SEQUENCE 202 AA; 22812 MW; 51798F2D0F6D8B45 CRC64;
MAASAALILP ESPSMKKAVP LINAIDTGRF PRLLSRILQK LHLKAESSFS EEEEEKLQAA
FSLEKQELHL VLETISFVLE QAVYHNVKPA ALQQQLEMIH LRKDKAEAFA SAWSAMGQET
VEKFRQRILG PHKLETVGWQ LNLQMAHSAQ AKLQSPQAVL QLGVSKEDAK NVEKVLVEFN
HKELFDFYNK LETIQAQLDS LT
