ID   COME_HAEIN              Reviewed;         445 AA.
AC   P31772;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Competence protein E;
DE   AltName: Full=DNA transformation protein ComE;
DE   Flags: Precursor;
GN   Name=comE; OrderedLocusNames=HI_0435;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=1916268; DOI=10.1016/0378-1119(91)90457-m;
RA   Tomb J.-F., El-Hajj H., Smith H.O.;
RT   "Nucleotide sequence of a cluster of genes involved in the transformation
RT   of Haemophilus influenzae Rd.";
RL   Gene 104:1-10(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 75-445.
RX   PubMed=1856167; DOI=10.1128/jb.173.15.4683-4691.1991;
RA   Larson T.G., Goodgal S.H.;
RT   "Sequence and transcriptional regulation of com101A, a locus required for
RT   genetic transformation in Haemophilus influenzae.";
RL   J. Bacteriol. 173:4683-4691(1991).
CC   -!- FUNCTION: Involved in transformation (competence for DNA uptake).
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bacterial secretin family. PilQ subfamily.
CC       {ECO:0000305}.
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DR   EMBL; M62809; AAA25012.1; -; Genomic_DNA.
DR   EMBL; L42023; AAC22094.1; -; Genomic_DNA.
DR   EMBL; M59751; AAA24947.1; -; Genomic_DNA.
DR   PIR; H64067; H64067.
DR   RefSeq; NP_438596.1; NC_000907.1.
DR   RefSeq; WP_005693728.1; NC_000907.1.
DR   AlphaFoldDB; P31772; -.
DR   SMR; P31772; -.
DR   STRING; 71421.HI_0435; -.
DR   TCDB; 1.B.22.4.1; the outer bacterial membrane secretin (secretin) family.
DR   EnsemblBacteria; AAC22094; AAC22094; HI_0435.
DR   KEGG; hin:HI_0435; -.
DR   PATRIC; fig|71421.8.peg.455; -.
DR   eggNOG; COG4796; Bacteria.
DR   HOGENOM; CLU_006756_2_1_6; -.
DR   OMA; QHTRREL; -.
DR   PhylomeDB; P31772; -.
DR   BioCyc; HINF71421:G1GJ1-450-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 3.30.1370.120; -; 1.
DR   InterPro; IPR001775; GspD/PilQ.
DR   InterPro; IPR005644; NolW-like.
DR   InterPro; IPR038591; NolW-like_sf.
DR   InterPro; IPR013355; Pilus_4_PilQ.
DR   InterPro; IPR004846; T2SS/T3SS.
DR   InterPro; IPR004845; T2SS_GspD_CS.
DR   Pfam; PF00263; Secretin; 1.
DR   Pfam; PF03958; Secretin_N; 1.
DR   PRINTS; PR00811; BCTERIALGSPD.
DR   TIGRFAMs; TIGR02515; IV_pilus_PilQ; 1.
DR   PROSITE; PS00875; T2SP_D; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Competence; Membrane; Reference proteome; Signal;
KW   Transport.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..445
FT                   /note="Competence protein E"
FT                   /id="PRO_0000013121"
FT   CONFLICT        433..443
FT                   /note="TLEALKQKSEG -> NVRGVET (in Ref. 1; AAA25012)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   445 AA;  49208 MW;  0901DA0D3D42D0E2 CRC64;
     MKKYFLKCGY FLVCFCLPLI VFANPKTDNE RFFIRLSQAP LAQTLEQLAF QQDVNLVIGD
     ILENKISLKL NNIDMPRLLQ IIAKSKHLTL NKDDGIYYLN GSQSGKGQVA GNLTTNEPHL
     VSHTVKLHFA KASELMKSLT TGSGSLLSPA GSITFDDRSN LLVIQDEPRS VQNIKKLIAE
     MDKPIEQIAI EARIVTITDE SLKELGVRWG IFNPTENARR VAGSLTGNSF ENIADNLNVN
     FATTTTPAGS IALQVAKING RLLDLELSAL ERENNVEIIA SPRLLTTNKK SASIKQGTEI
     PYIVSNTRND TQSVEFREAV LGLEVTPHIS KDNNILLDLL VSQNSPGSRV AYGQNEVVSI
     DKQEINTQVF AKDGETIVLG GVFHDTITKS EDKVPLLGDI PVIKRLFSKE SERHQKRELV
     IFVTPHILKA GETLEALKQK SEGKK