ID   COMM2_AEDAE             Reviewed;         292 AA.
AC   Q172W0;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Protein commissureless 2 homolog {ECO:0000303|PubMed:24026811};
GN   Name=comm2 {ECO:0000303|PubMed:24026811};
GN   ORFNames=AAEL007250 {ECO:0000312|EMBL:EAT41069.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000312|Proteomes:UP000008820};
RN   [1] {ECO:0000312|Proteomes:UP000008820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12 {ECO:0000312|Proteomes:UP000008820};
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
RN   [2] {ECO:0000305}
RP   FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=24026811; DOI=10.1002/dvdy.24059;
RA   Sarro J., Andrews E., Sun L., Behura S.K., Tan J.C., Zeng E.,
RA   Severson D.W., Duman-Scheel M.;
RT   "Requirement for commissureless2 function during dipteran insect nerve cord
RT   development.";
RL   Dev. Dyn. 242:1466-1477(2013).
CC   -!- FUNCTION: Essential for nerve cord development. Functions downstream of
CC       fra to control axon guidance across the central nervous system (CNS)
CC       midline. {ECO:0000269|PubMed:24026811}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DEVELOPMENTAL STAGE: In embryos expressed in the brain and overlying
CC       head tissue. Expressed in the ventral nerve cord at the onset of
CC       commissural axon guidance toward the midline. Expression levels in the
CC       ventral nerve cord peak in 50 hour old embryos. By 52 hours expression
CC       becomes restricted and appears to be expressed specifically in neurons
CC       which cross the midline such as EG, RP1, RP3 and RP4. At 54 hours, when
CC       most commissural axons have crossed the midline, expression levels in
CC       the nerve cord was no longer detected. {ECO:0000269|PubMed:24026811}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in thinning or
CC       even complete loss of commissural axons in embryonic nerve cords.
CC       {ECO:0000269|PubMed:24026811}.
CC   -!- SIMILARITY: Belongs to the commissureless family. {ECO:0000305}.
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DR   EMBL; CH477430; EAT41069.1; -; Genomic_DNA.
DR   RefSeq; XP_001652624.1; XM_001652574.1.
DR   AlphaFoldDB; Q172W0; -.
DR   SMR; Q172W0; -.
DR   STRING; 7159.AAEL007250-PA; -.
DR   GeneID; 5568959; -.
DR   KEGG; aag:5568959; -.
DR   VEuPathDB; VectorBase:AAEL007250; -.
DR   eggNOG; ENOG502STQJ; Eukaryota.
DR   HOGENOM; CLU_953818_0_0_1; -.
DR   InParanoid; Q172W0; -.
DR   OMA; YLWIGAV; -.
DR   OrthoDB; 1425094at2759; -.
DR   PhylomeDB; Q172W0; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR   InterPro; IPR031878; Commissureless.
DR   Pfam; PF15957; Comm; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..292
FT                   /note="Protein commissureless 2 homolog"
FT                   /id="PRO_0000438382"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           163..166
FT                   /note="PY-motif 1"
FT                   /evidence="ECO:0000250|UniProtKB:Q24139"
FT   MOTIF           172..175
FT                   /note="PY-motif 2"
FT                   /evidence="ECO:0000250|UniProtKB:Q24139"
SQ   SEQUENCE   292 AA;  32468 MW;  E58E605A5FE85E84 CRC64;
     MIDSLESKIT FEIPNNLDFN KFIRENNYSS FWQNLHQQET AARVAAMSSL GMGVSEPLRT
     SEYNASDFNL LSSLQNFAGR AGPVGFSADG SEQLLDPTYE RFIGDVWVGI VLTLMILSSI
     FCMCSCFLYH KFRQWQRSVL TARSQTLSSM DLETPPPYDV ESLPSYTIVS GLPSYNDAIE
     QLKQKQQQKS PGGHLEPVKL QRPSVIKLFE SQSQDLLAGA KLEEIRYNFA NNLTTSVVSE
     NSFDVTPTTS SNTAVNATTV AVAPNFKTQV STSMPKKFTV CNYSVENERS GS