COMM2_DROME
ID COMM2_DROME Reviewed; 343 AA.
AC Q9VUT8; Q8MZ29;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein commissureless 2 {ECO:0000303|PubMed:24026811};
GN Name=comm2 {ECO:0000303|PubMed:24026811, ECO:0000312|FlyBase:FBgn0041160};
GN ORFNames=CG7554 {ECO:0000312|FlyBase:FBgn0041160};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAM29394.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAM29394.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAM29394.1};
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.;
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=24026811; DOI=10.1002/dvdy.24059;
RA Sarro J., Andrews E., Sun L., Behura S.K., Tan J.C., Zeng E.,
RA Severson D.W., Duman-Scheel M.;
RT "Requirement for commissureless2 function during dipteran insect nerve cord
RT development.";
RL Dev. Dyn. 242:1466-1477(2013).
CC -!- FUNCTION: Essential for nerve cord development. Functions downstream of
CC fra to control axon guidance across the central nervous system (CNS)
CC midline. {ECO:0000269|PubMed:24026811}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- DEVELOPMENTAL STAGE: In embryos expressed in the nerve cord, brain and
CC overlying head tissue. Expression levels in the ventral nerve cord peak
CC in stage 13 embryos. By stage 15 expression becomes restricted and
CC appears to be expressed specifically in neurons which cross the
CC midline. Expression levels decrease once most of the commissural axons
CC have crossed the midline. {ECO:0000269|PubMed:24026811}.
CC -!- SIMILARITY: Belongs to the commissureless family. {ECO:0000305}.
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DR EMBL; AE014296; AAF49585.2; -; Genomic_DNA.
DR EMBL; AY113389; AAM29394.1; -; mRNA.
DR RefSeq; NP_648801.2; NM_140544.2.
DR AlphaFoldDB; Q9VUT8; -.
DR SMR; Q9VUT8; -.
DR IntAct; Q9VUT8; 7.
DR STRING; 7227.FBpp0075333; -.
DR PaxDb; Q9VUT8; -.
DR DNASU; 39716; -.
DR EnsemblMetazoa; FBtr0075580; FBpp0075333; FBgn0041160.
DR GeneID; 39716; -.
DR KEGG; dme:Dmel_CG7554; -.
DR UCSC; CG7554-RA; d. melanogaster.
DR CTD; 39716; -.
DR FlyBase; FBgn0041160; comm2.
DR VEuPathDB; VectorBase:FBgn0041160; -.
DR eggNOG; ENOG502T83U; Eukaryota.
DR HOGENOM; CLU_070179_0_0_1; -.
DR InParanoid; Q9VUT8; -.
DR OMA; IQLKHHH; -.
DR OrthoDB; 1005171at2759; -.
DR PhylomeDB; Q9VUT8; -.
DR BioGRID-ORCS; 39716; 0 hits in 1 CRISPR screen.
DR ChiTaRS; comm2; fly.
DR GenomeRNAi; 39716; -.
DR PRO; PR:Q9VUT8; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0041160; Expressed in anlage in statu nascendi and 75 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR InterPro; IPR031878; Commissureless.
DR Pfam; PF15957; Comm; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..343
FT /note="Protein commissureless 2"
FT /id="PRO_0000438381"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 228..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 191..194
FT /note="PY-motif"
FT /evidence="ECO:0000250|UniProtKB:Q24139"
SQ SEQUENCE 343 AA; 37728 MW; 7D7C874EDFB10EB4 CRC64;
MEELPRALNY ELSHDLHFDH YAGAAAQKIL NSGRSSPEAS TPTITTLDAI SSSDFLKQIG
QQILSSIQLK HQHQLNEVSH PRNSTSEEIM DFDLANRVIL DSSSVDQLQQ QLEYDKFMNE
VWIGIVFTLI LISMVFCICS CFLYHQFRTW KRNYRNNANG STQCTIVDIE ALKLHPDVED
PVPEYTLVSG LPSYEAALEL LQKSPQSSCL IVYPSVFNVF NKQERSSQEL QHPGVATSAP
PAAPENHLAP QTPSFCDATM PLLPATTAAA ATHAAATVTA VTAATATSAT LAASPTCESI
KPNFVMMPIV PSYAEVFGSS YKTVDEKKKS KSKDSQSKDD IKR
