COMN_BACSU
ID COMN_BACSU Reviewed; 98 AA.
AC O32049;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Post-transcriptional regulator ComN;
GN Name=comN; Synonyms=yrzD; OrderedLocusNames=BSU27660;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [2]
RP FUNCTION, DISRUPTION PHENOTYPE, AND GENE NAME.
RC STRAIN=168;
RX PubMed=19028902; DOI=10.1128/jb.01429-08;
RA Ogura M., Tanaka T.;
RT "The Bacillus subtilis late competence operon comE is transcriptionally
RT regulated by yutB and under post-transcription initiation control by comN
RT (yrzD).";
RL J. Bacteriol. 191:949-958(2009).
RN [3]
RP FUNCTION, INTERACTION WITH DIVIVA, SUBCELLULAR LOCATION, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=168 / PY79;
RX PubMed=22582279; DOI=10.1128/jb.05879-11;
RA Dos Santos V.T., Bisson-Filho A.W., Gueiros-Filho F.J.;
RT "DivIVA-mediated polar localization of ComN, a posttranscriptional
RT regulator of Bacillus subtilis.";
RL J. Bacteriol. 194:3661-3669(2012).
CC -!- FUNCTION: Required for post-transcription initiation control of the
CC comE operon. Promotes the accumulation of its target comE mRNA to
CC septal and polar sites. {ECO:0000269|PubMed:19028902,
CC ECO:0000269|PubMed:22582279}.
CC -!- SUBUNIT: Interacts directly with DivIVA. {ECO:0000269|PubMed:22582279}.
CC -!- INTERACTION:
CC O32049; P71021: divIVA; NbExp=4; IntAct=EBI-6418652, EBI-5243654;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22582279}.
CC Note=Localizes to the division site and cell poles, in a DivIVA-
CC dependent manner. Polar localization is not essential for competence
CC development.
CC -!- DISRUPTION PHENOTYPE: Disruption results in severely reduced
CC transformation frequency, but has no detectable effect on either the
CC frequency or the location of division septa.
CC {ECO:0000269|PubMed:19028902, ECO:0000269|PubMed:22582279}.
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DR EMBL; AL009126; CAB14726.1; -; Genomic_DNA.
DR PIR; C69982; C69982.
DR RefSeq; NP_390644.1; NC_000964.3.
DR RefSeq; WP_004398498.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; O32049; -.
DR IntAct; O32049; 1.
DR STRING; 224308.BSU27660; -.
DR PaxDb; O32049; -.
DR PRIDE; O32049; -.
DR EnsemblBacteria; CAB14726; CAB14726; BSU_27660.
DR GeneID; 937536; -.
DR KEGG; bsu:BSU27660; -.
DR PATRIC; fig|224308.179.peg.3005; -.
DR eggNOG; ENOG503318Y; Bacteria.
DR OMA; FMNYATV; -.
DR PhylomeDB; O32049; -.
DR BioCyc; BSUB:BSU27660-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR InterPro; IPR025716; Post-transcriptional_regulator.
DR Pfam; PF13797; Post_transc_reg; 1.
PE 1: Evidence at protein level;
KW Competence; Cytoplasm; Reference proteome.
FT CHAIN 1..98
FT /note="Post-transcriptional regulator ComN"
FT /id="PRO_0000360745"
SQ SEQUENCE 98 AA; 11586 MW; BD5CBEA9FC21DF61 CRC64;
MEKHPADLYK DHVRPFLYSK LEEFKILGYD DVELESLWSY LTDKKWKKKT ELSIYELASD
ILSVKIGEFM NYATVESFKT SNWLGSEEGQ EALEELLR