2ABG_HUMAN
ID 2ABG_HUMAN Reviewed; 447 AA.
AC Q9Y2T4; A8MSY7; B7Z3Y1; Q7Z4V7; Q8NEC4; Q9H3G7;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 4.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform;
DE AltName: Full=IMYPNO1;
DE AltName: Full=PP2A subunit B isoform B55-gamma;
DE AltName: Full=PP2A subunit B isoform PR55-gamma;
DE AltName: Full=PP2A subunit B isoform R2-gamma;
DE AltName: Full=PP2A subunit B isoform gamma;
GN Name=PPP2R2C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10574460; DOI=10.1093/dnares/6.5.323;
RA Torres R., Ide S.E., Dehejia A., Baras A., Polymeropoulos M.H.;
RT "Genomic structure and localization of the human phosphatase 2A BR gamma
RT regulatory subunit.";
RL DNA Res. 6:323-327(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10945473; DOI=10.1006/geno.2000.6219;
RA Hu P., Yu L., Zhang M., Zheng L., Zhao Y., Fu Q., Zhao S.;
RT "Molecular cloning and mapping of the brain-abundant B1gamma subunit of
RT protein phosphatase 2A, PPP2R2C, to human chromosome 4p16.";
RL Genomics 67:83-86(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Yu L., Zhao S.Y.;
RT "Cloning of a new human cDNA homologous to Oryctolagus cuniculus protein
RT phosphatase 2A1 B gamma subunit.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
RC TISSUE=Brain, Testis, and Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP INTERACTION WITH IER5.
RX PubMed=25816751; DOI=10.1016/j.febslet.2015.03.019;
RA Ishikawa Y., Kawabata S., Sakurai H.;
RT "HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.";
RL FEBS Lett. 589:1150-1155(2015).
CC -!- FUNCTION: The B regulatory subunit might modulate substrate selectivity
CC and catalytic activity, and also might direct the localization of the
CC catalytic enzyme to a particular subcellular compartment.
CC -!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed
CC of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant
CC regulatory subunit (PR65 or subunit A), that associates with a variety
CC of regulatory subunits. Proteins that associate with the core dimer
CC include three families of regulatory subunits B (the R2/B/PR55/B55,
CC R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable
CC regulatory subunit, viral proteins, and cell signaling molecules (By
CC similarity). Interacts with IER5 (PubMed:25816751). {ECO:0000250,
CC ECO:0000269|PubMed:25816751}.
CC -!- INTERACTION:
CC Q9Y2T4; P67775: PPP2CA; NbExp=3; IntAct=EBI-1774058, EBI-712311;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9Y2T4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y2T4-2; Sequence=VSP_036457;
CC Name=3;
CC IsoId=Q9Y2T4-3; Sequence=VSP_036458;
CC Name=4;
CC IsoId=Q9Y2T4-4; Sequence=VSP_043380;
CC -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B family.
CC {ECO:0000305}.
CC -!- CAUTION: The EMBL entry for PubMed:10574460 is not complete, the paper
CC shows the rest of the sequence (residues 1 to 23). {ECO:0000305}.
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DR EMBL; AH007514; AAD20987.1; -; Genomic_DNA.
DR EMBL; AF086924; AAG39636.1; -; mRNA.
DR EMBL; AF145027; AAP97279.1; -; mRNA.
DR EMBL; AK093115; BAG52658.1; -; mRNA.
DR EMBL; AK296474; BAH12367.1; -; mRNA.
DR EMBL; AK316003; BAH14374.1; -; mRNA.
DR EMBL; AC093323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC114815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC116317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC122939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471131; EAW82393.1; -; Genomic_DNA.
DR EMBL; CH471131; EAW82394.1; -; Genomic_DNA.
DR EMBL; CH471131; EAW82395.1; -; Genomic_DNA.
DR EMBL; BC032954; AAH32954.1; -; mRNA.
DR CCDS; CCDS3387.1; -. [Q9Y2T4-1]
DR CCDS; CCDS3388.1; -. [Q9Y2T4-2]
DR CCDS; CCDS56304.1; -. [Q9Y2T4-3]
DR CCDS; CCDS56305.1; -. [Q9Y2T4-4]
DR PIR; JC7153; JC7153.
DR RefSeq; NP_001193923.1; NM_001206994.1. [Q9Y2T4-4]
DR RefSeq; NP_001193924.1; NM_001206995.1. [Q9Y2T4-4]
DR RefSeq; NP_001193925.1; NM_001206996.1. [Q9Y2T4-3]
DR RefSeq; NP_065149.2; NM_020416.3. [Q9Y2T4-1]
DR RefSeq; NP_870991.1; NM_181876.2. [Q9Y2T4-2]
DR AlphaFoldDB; Q9Y2T4; -.
DR SMR; Q9Y2T4; -.
DR BioGRID; 111514; 66.
DR IntAct; Q9Y2T4; 41.
DR MINT; Q9Y2T4; -.
DR STRING; 9606.ENSP00000335083; -.
DR iPTMnet; Q9Y2T4; -.
DR PhosphoSitePlus; Q9Y2T4; -.
DR BioMuta; PPP2R2C; -.
DR DMDM; 145559437; -.
DR EPD; Q9Y2T4; -.
DR jPOST; Q9Y2T4; -.
DR MassIVE; Q9Y2T4; -.
DR MaxQB; Q9Y2T4; -.
DR PaxDb; Q9Y2T4; -.
DR PeptideAtlas; Q9Y2T4; -.
DR PRIDE; Q9Y2T4; -.
DR ProteomicsDB; 85893; -.
DR ProteomicsDB; 85894; -. [Q9Y2T4-2]
DR ProteomicsDB; 85895; -. [Q9Y2T4-3]
DR ProteomicsDB; 85896; -. [Q9Y2T4-4]
DR Antibodypedia; 22656; 110 antibodies from 25 providers.
DR DNASU; 5522; -.
DR Ensembl; ENST00000335585.9; ENSP00000335083.5; ENSG00000074211.14. [Q9Y2T4-2]
DR Ensembl; ENST00000382599.9; ENSP00000372042.4; ENSG00000074211.14. [Q9Y2T4-1]
DR Ensembl; ENST00000506140.5; ENSP00000423649.1; ENSG00000074211.14. [Q9Y2T4-4]
DR Ensembl; ENST00000507294.1; ENSP00000425247.1; ENSG00000074211.14. [Q9Y2T4-4]
DR Ensembl; ENST00000515571.5; ENSP00000422374.1; ENSG00000074211.14. [Q9Y2T4-3]
DR GeneID; 5522; -.
DR KEGG; hsa:5522; -.
DR MANE-Select; ENST00000382599.9; ENSP00000372042.4; NM_020416.4; NP_065149.2.
DR UCSC; uc003gja.3; human. [Q9Y2T4-1]
DR CTD; 5522; -.
DR DisGeNET; 5522; -.
DR GeneCards; PPP2R2C; -.
DR HGNC; HGNC:9306; PPP2R2C.
DR HPA; ENSG00000074211; Tissue enhanced (brain).
DR MIM; 605997; gene.
DR neXtProt; NX_Q9Y2T4; -.
DR OpenTargets; ENSG00000074211; -.
DR PharmGKB; PA33670; -.
DR VEuPathDB; HostDB:ENSG00000074211; -.
DR eggNOG; KOG1354; Eukaryota.
DR GeneTree; ENSGT00950000182864; -.
DR HOGENOM; CLU_021713_3_3_1; -.
DR InParanoid; Q9Y2T4; -.
DR OMA; EFRYKSE; -.
DR OrthoDB; 810409at2759; -.
DR PhylomeDB; Q9Y2T4; -.
DR TreeFam; TF105553; -.
DR PathwayCommons; Q9Y2T4; -.
DR SignaLink; Q9Y2T4; -.
DR SIGNOR; Q9Y2T4; -.
DR BioGRID-ORCS; 5522; 7 hits in 1066 CRISPR screens.
DR ChiTaRS; PPP2R2C; human.
DR GeneWiki; PPP2R2C; -.
DR GenomeRNAi; 5522; -.
DR Pharos; Q9Y2T4; Tbio.
DR PRO; PR:Q9Y2T4; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q9Y2T4; protein.
DR Bgee; ENSG00000074211; Expressed in middle temporal gyrus and 160 other tissues.
DR ExpressionAtlas; Q9Y2T4; baseline and differential.
DR Genevisible; Q9Y2T4; HS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0000159; C:protein phosphatase type 2A complex; IBA:GO_Central.
DR GO; GO:0019888; F:protein phosphatase regulator activity; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR000009; PP2A_PR55.
DR InterPro; IPR018067; PP2A_PR55_CS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR11871; PTHR11871; 1.
DR PIRSF; PIRSF037309; PP2A_PR55; 1.
DR PRINTS; PR00600; PP2APR55.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS01024; PR55_1; 1.
DR PROSITE; PS01025; PR55_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..447
FT /note="Serine/threonine-protein phosphatase 2A 55 kDa
FT regulatory subunit B gamma isoform"
FT /id="PRO_0000071428"
FT REPEAT 22..61
FT /note="WD 1"
FT REPEAT 87..128
FT /note="WD 2"
FT REPEAT 171..209
FT /note="WD 3"
FT REPEAT 220..260
FT /note="WD 4"
FT REPEAT 279..317
FT /note="WD 5"
FT REPEAT 334..375
FT /note="WD 6"
FT REPEAT 410..446
FT /note="WD 7"
FT VAR_SEQ 1..23
FT /note="MGEDTDTRKINHSFLRDHSYVTE -> MGLSFFSKHLPIQEGQPWALKTP
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_036457"
FT VAR_SEQ 1..23
FT /note="MGEDTDTRKINHSFLRDHSYVTE -> MGKRDT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_036458"
FT VAR_SEQ 1..23
FT /note="MGEDTDTRKINHSFLRDHSYVTE -> MREADTLRPPQLMEVS (in
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043380"
FT CONFLICT 66
FT /note="E -> D (in Ref. 2; AAG39636)"
FT /evidence="ECO:0000305"
FT CONFLICT 253
FT /note="R -> P (in Ref. 2; AAG39636)"
FT /evidence="ECO:0000305"
FT CONFLICT 293
FT /note="G -> D (in Ref. 2; AAG39636 and 3; AAP97279)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 447 AA; 51515 MW; DB002C2384686BBD CRC64;
MGEDTDTRKI NHSFLRDHSY VTEADIISTV EFNHTGELLA TGDKGGRVVI FQREPESKNA
PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ QNAAHSLLST NDKTIKLWKI
TERDKRPEGY NLKDEEGKLK DLSTVTSLQV PVLKPMDLMV EVSPRRIFAN GHTYHINSIS
VNSDCETYMS ADDLRINLWH LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY
SSSKGSLRLC DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD
YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYENDCIFD KFECAWNGSD SVIMTGAYNN
FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR RDDISVDSLD FTKKILHTAW
HPAENIIAIA ATNNLYIFQD KVNSDMH
