COMR_ECOLI
ID COMR_ECOLI Reviewed; 210 AA.
AC P75952; Q9R7N8; Q9R7N9;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=HTH-type transcriptional repressor ComR;
DE AltName: Full=Copper outer membrane regulator;
GN Name=comR; Synonyms=ycfQ; OrderedLocusNames=b1111, JW5159;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP FUNCTION, DNA-BINDING, ACTIVITY REGULATION, DISRUPTION PHENOTYPE, AND GENE
RP NAME.
RX PubMed=22089859; DOI=10.1007/s10534-011-9510-x;
RA Mermod M., Magnani D., Solioz M., Stoyanov J.V.;
RT "The copper-inducible ComR (YcfQ) repressor regulates expression of ComC
RT (YcfR), which affects copper permeability of the outer membrane of
RT Escherichia coli.";
RL BioMetals 25:33-43(2012).
CC -!- FUNCTION: Represses expression of BhsA/ComC by binding to its promoter
CC region in the absence of copper. {ECO:0000269|PubMed:22089859}.
CC -!- ACTIVITY REGULATION: Binding to the promoter region of BhsA/ComC is
CC released in the presence of copper. {ECO:0000269|PubMed:22089859}.
CC -!- DISRUPTION PHENOTYPE: Deletion mutants contain lower cytoplasmic copper
CC levels compared to the wild-type strain when exposed to copper.
CC {ECO:0000269|PubMed:22089859}.
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DR EMBL; U00096; AAC74195.2; -; Genomic_DNA.
DR EMBL; AP009048; BAA35926.2; -; Genomic_DNA.
DR RefSeq; NP_415629.4; NC_000913.3.
DR RefSeq; WP_001336528.1; NZ_SSZK01000019.1.
DR AlphaFoldDB; P75952; -.
DR SMR; P75952; -.
DR BioGRID; 4260995; 6.
DR STRING; 511145.b1111; -.
DR jPOST; P75952; -.
DR PaxDb; P75952; -.
DR PRIDE; P75952; -.
DR EnsemblBacteria; AAC74195; AAC74195; b1111.
DR EnsemblBacteria; BAA35926; BAA35926; BAA35926.
DR GeneID; 947425; -.
DR KEGG; ecj:JW5159; -.
DR KEGG; eco:b1111; -.
DR PATRIC; fig|511145.12.peg.1155; -.
DR EchoBASE; EB3209; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_069356_28_0_6; -.
DR InParanoid; P75952; -.
DR OMA; MAVQATN; -.
DR PhylomeDB; P75952; -.
DR BioCyc; EcoCyc:G6569-MON; -.
DR PRO; PR:P75952; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003677; F:DNA binding; IDA:EcoCyc.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEP:EcoCyc.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0046688; P:response to copper ion; IDA:EcoCyc.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF48498; SSF48498; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 1: Evidence at protein level;
KW Copper; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..210
FT /note="HTH-type transcriptional repressor ComR"
FT /id="PRO_0000070638"
FT DOMAIN 18..78
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT DNA_BIND 41..60
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 210 AA; 23362 MW; 8C1D523668756E42 CRC64;
MATDSTQCVK KSRGRPKVFD RDAALDKAMK LFWQHGYEAT SLADLVEATG AKAPTLYAEF
TNKEGLFRAV LDRYIDRFAA KHEAQLFCEE KSVESALADY FAAIANCFTS KDTPAGCFMI
NNCTTLSPDS GDIANTLKSR HAMQERTLQQ FLCQRQARGE IPPHCDVTHL AEFLNCIIQG
MSISAREGAS LEKLMQIAGT TLRLWPELVK
