ID   COM_BPD10               Reviewed;          62 AA.
AC   Q38200; C9DGR3;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   11-JUN-2014, sequence version 2.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Translational activator com;
DE   AltName: Full=Gene product com;
DE            Short=gpCom;
GN   Name=com;
OS   Escherichia phage D108 (Bacteriophage D108).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Muvirus; unclassified Muvirus.
OX   NCBI_TaxID=665033;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kropinski A.M., Villegas A., Lingohr E.J.;
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-38.
RX   PubMed=2957646; DOI=10.1093/nar/15.16.6691;
RA   Szatmari G.B., Lapointe M., Dubow M.S.;
RT   "The right end of transposable bacteriophage D108 contains a 520 base pair
RT   protein-encoding sequence not present in bacteriophage Mu.";
RL   Nucleic Acids Res. 15:6691-6704(1987).
CC   -!- FUNCTION: Trans-acting positive regulator required for mom mRNA
CC       translation. Binds the com-mom mRNA 5' and destabilizes a translation
CC       inhibition stem to expose mom translation start signals (By
CC       similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=One Zn(2+) per molecule. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       Expression of late genes is activated by the viral late transcription
CC       activator C.
CC   -!- SIMILARITY: Belongs to the com family. {ECO:0000305}.
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DR   EMBL; GQ357916; ACV50314.1; -; Genomic_DNA.
DR   EMBL; X05926; CAA29366.1; -; Genomic_DNA.
DR   PIR; S07972; S07972.
DR   RefSeq; YP_003335803.1; NC_013594.1.
DR   GeneID; 8658866; -.
DR   KEGG; vg:8658866; -.
DR   Proteomes; UP000000320; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR019294; Translation_reg_Com.
DR   Pfam; PF10122; Mu-like_Com; 1.
PE   2: Evidence at transcript level;
KW   Activator; Host cytoplasm; Late protein; Metal-binding; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..62
FT                   /note="Translational activator com"
FT                   /id="PRO_0000077661"
FT   ZN_FING         6..29
FT                   /note="Atypical"
FT                   /evidence="ECO:0000250"
FT   BINDING         6
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         9
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         26
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         29
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   62 AA;  7414 MW;  08016BBFBFD3D2B6 CRC64;
     MKSIRCKNCN KLLFKADSFD HIEIRCPRCK RHIIMLNACE HPTEKHCGKR EKITHSDETV
     RY