ID   CON1_CONLT              Reviewed;          85 AA.
AC   Q2I2P1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Contulakin-Lt1;
DE   Flags: Precursor;
OS   Conus litteratus (Lettered cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Elisaconus.
OX   NCBI_TaxID=89445;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16908117; DOI=10.1016/j.ygeno.2006.06.014;
RA   Pi C., Liu J., Peng C., Liu Y., Jiang X., Zhao Y., Tang S., Wang L.,
RA   Dong M., Chen S., Xu A.;
RT   "Diversity and evolution of conotoxins based on gene expression profiling
RT   of Conus litteratus.";
RL   Genomics 88:809-819(2006).
CC   -!- FUNCTION: Acts as an agonist of neurotensin receptors. It binds to
CC       human neurotensin type 1 receptor (NTSR1), rat neurotensin types 1 and
CC       2 receptors (NTSR1/NTSR2) and mouse neurotensin type 3 receptor (SORT1)
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is C-C.
CC   -!- SIMILARITY: Belongs to the conotoxin C superfamily. {ECO:0000305}.
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DR   EMBL; DQ345391; ABC74999.1; -; mRNA.
DR   AlphaFoldDB; Q2I2P1; -.
DR   TCDB; 8.B.36.1.1; the contulakin lt (contulakin lt) family.
DR   ConoServer; 1177; Contulakin-Lt1 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   G-protein coupled receptor impairing toxin; Neurotoxin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..60
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000315411"
FT   PEPTIDE         61..75
FT                   /note="Contulakin-Lt1"
FT                   /id="PRO_0000315412"
FT   PROPEP          76..85
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000315413"
FT   DISULFID        65..70
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   85 AA;  9856 MW;  DF603C564CDFD181 CRC64;
     MRTAYWVMVM MMVGITAPLS EGRKLNDAIR GLVADYLTPQ LLQSLVSAPY PEFQLDDPNL
     EIPVCIWKVC PPIPWRRRDL KKRNK