CON7_MAGO7
ID CON7_MAGO7 Reviewed; 402 AA.
AC G4N5Q2; Q069J4;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 17-FEB-2016, sequence version 2.
DT 25-MAY-2022, entry version 47.
DE RecName: Full=C2H2 finger domain transcription factor CON7 {ECO:0000305};
GN Name=CON7 {ECO:0000303|Ref.3}; ORFNames=MGG_05287;
OS Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS fungus) (Pyricularia oryzae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX NCBI_TaxID=242507;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND
RP FUNCTION.
RC STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX PubMed=17378924; DOI=10.1111/j.1365-2958.2007.05643.x;
RA Odenbach D., Breth B., Thines E., Weber R.W., Anke H., Foster A.J.;
RT "The transcription factor Con7p is a central regulator of infection-related
RT morphogenesis in the rice blast fungus Magnaporthe grisea.";
RL Mol. Microbiol. 64:293-307(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX PubMed=15846337; DOI=10.1038/nature03449;
RA Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL Nature 434:980-986(2005).
RN [3]
RP IDENTIFICATION, AND DISRUPTION PHENOTYPE.
RX DOI=10.1094/MPMI-8-0949;
RA Shi Z., Leung H.;
RT "Genetic analysis of sporulation in Magnaporthe grisea by chemical and
RT insertional mutagenesis.";
RL Mol. Plant Microbe Interact. 8:949-959(1995).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=9487695; DOI=10.1094/mpmi.1998.11.3.199;
RA Shi Z., Christian D., Leung H.;
RT "Interactions between spore morphogenetic mutations affect cell types,
RT sporulation, and pathogenesis in Magnaporthe grisea.";
RL Mol. Plant Microbe Interact. 11:199-207(1998).
CC -!- FUNCTION: Transcription factor that plays a central role in
CC appressorium formation and pathogenicity (PubMed:17378924,
CC PubMed:9487695). Required for the expression of a large set of genes
CC including factors that might play a role in membrane metabolism and
CC ergosterol biosynthesis, the chitin-binding protein CBP1,as well as
CC CHS7 that is essential for normal pathogenic development
CC (PubMed:17378924). {ECO:0000269|PubMed:17378924,
CC ECO:0000269|PubMed:9487695}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17378924}.
CC -!- DISRUPTION PHENOTYPE: Impairs appressorium formation and growth in
CC plant hosts. {ECO:0000269|PubMed:17378924, ECO:0000269|PubMed:9487695,
CC ECO:0000269|Ref.3}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EHA53042.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DQ985585; ABI96241.1; -; mRNA.
DR EMBL; CM001233; EHA53042.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_003712849.1; XM_003712801.1.
DR AlphaFoldDB; G4N5Q2; -.
DR SMR; G4N5Q2; -.
DR STRING; 318829.MGG_05287T0; -.
DR EnsemblFungi; MGG_05287T0; MGG_05287T0; MGG_05287.
DR GeneID; 2675319; -.
DR KEGG; mgr:MGG_05287; -.
DR eggNOG; ENOG502S48N; Eukaryota.
DR HOGENOM; CLU_030366_0_0_1; -.
DR InParanoid; G4N5Q2; -.
DR OrthoDB; 1057131at2759; -.
DR PHI-base; PHI:2039; -.
DR Proteomes; UP000009058; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR039327; CON7-like.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR36167; PTHR36167; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Virulence; Zinc; Zinc-finger.
FT CHAIN 1..402
FT /note="C2H2 finger domain transcription factor CON7"
FT /id="PRO_0000435643"
FT ZN_FING 256..282
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 289..323
FT /evidence="ECO:0000255"
FT COMPBIAS 22..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 402 AA; 43527 MW; 7AE309EB9FF78BBE CRC64;
MLASSRQPRH AFVEHHHQLS SSTLHRSGSP QTGTLRQDAT TPTLATSVGP SMDRSASDYS
QSGLPSPYPS NCGDNQSEAQ SVTVDTSSAA QYNASAQQEV RSNNPGNYSA SATPTSEYGV
YPASARSSSF PDHLQQRSYH PASNHSGSSG DPSIAAPSPT YGAPAQYSPY GPPSQDMSHG
YAHPGSNLYA QPRPDWSGYG QQHGAPLTPG HHVFPQTPTS APPQARPNQV YSFVPIPGAQ
QHKRPRRRYE EIERMYKCGW QGCEKAYGTL NHLNAHVTMQ SHGQKRTPEE FKEIRKEWKA
RKKEEEAARK ADEERQRQAA QSQGGSTEGQ AGSDVSQSSN GYAGARGAVQ LPPIGYQAGQ
YPAATSTSVQ QQPLPDYNAS YMQGYQPASP YGGSNQAMYN QR
