COND2_LUPAN
ID COND2_LUPAN Reviewed; 153 AA.
AC Q99235;
DT 16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Conglutin delta 2 {ECO:0000303|PubMed:21457583};
DE AltName: Allergen=Lup an delta-conglutin {ECO:0000305};
DE Contains:
DE RecName: Full=Conglutin delta-2 large chain {ECO:0000250|UniProtKB:F5B8W8};
DE Contains:
DE RecName: Full=Conglutin delta-2 small chain {ECO:0000250|UniProtKB:F5B8W8};
DE Flags: Precursor;
GN ORFNames=TanjilG_23180 {ECO:0000312|EMBL:OIW20800.1};
OS Lupinus angustifolius (Narrow-leaved blue lupine).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC genistoids sensu lato; core genistoids; Genisteae; Lupinus.
OX NCBI_TaxID=3871;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Unicrop; TISSUE=Cotyledon;
RX PubMed=2103479; DOI=10.1007/bf00039427;
RA Gayler K.R., Kolivas S., Macfarlane A.J., Lilley G.G., Baldi M.,
RA Blagrove R.J., Johnson E.D.;
RT "Biosynthesis, cDNA and amino acid sequences of a precursor of conglutin
RT delta, a sulphur-rich protein from Lupinus angustifolius.";
RL Plant Mol. Biol. 15:879-893(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND ALLERGEN.
RC STRAIN=cv. Tanjil; TISSUE=Seed;
RX PubMed=21457583; DOI=10.1186/1471-2229-11-59;
RA Foley R.C., Gao L.-L., Spriggs A., Soo L.Y.C., Goggin D.E., Smith P.M.C.,
RA Atkins C.A., Singh K.B.;
RT "Identification and characterisation of seed storage protein transcripts
RT from Lupinus angustifolius.";
RL BMC Plant Biol. 11:59-59(2011).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Tanjil; TISSUE=Seedling;
RX PubMed=27557478; DOI=10.1111/pbi.12615;
RA Hane J.K., Ming Y., Kamphuis L.G., Nelson M.N., Garg G., Atkins C.A.,
RA Bayer P.E., Bravo A., Bringans S., Cannon S., Edwards D., Foley R.,
RA Gao L.L., Harrison M.J., Huang W., Hurgobin B., Li S., Liu C.W.,
RA McGrath A., Morahan G., Murray J., Weller J., Jian J., Singh K.B.;
RT "A comprehensive draft genome sequence for lupin (Lupinus angustifolius),
RT an emerging health food: insights into plant-microbe interactions and
RT legume evolution.";
RL Plant Biotechnol. J. 15:318-330(2017).
CC -!- SUBUNIT: Heterodimer of a small chain and a large chain; disulfide-
CC linked. {ECO:0000250|UniProtKB:F5B8W8}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000269|PubMed:2103479}.
CC -!- TISSUE SPECIFICITY: Expressed in developing cotyledons (at protein
CC level). {ECO:0000269|PubMed:2103479}.
CC -!- DEVELOPMENTAL STAGE: Accumulates during seed development.
CC {ECO:0000269|PubMed:21457583}.
CC -!- ALLERGEN: Causes an allergic reaction in human.
CC {ECO:0000305|PubMed:21457583}.
CC -!- SIMILARITY: Belongs to the 2S seed storage albumins family.
CC {ECO:0000305}.
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DR EMBL; X53523; CAA37598.1; -; mRNA.
DR EMBL; HQ670419; AEB33722.1; -; mRNA.
DR EMBL; MLAU01014968; OIW20800.1; -; Genomic_DNA.
DR PIR; S12404; A33090.
DR RefSeq; XP_019431756.1; XM_019576211.1.
DR AlphaFoldDB; Q99235; -.
DR SMR; Q99235; -.
DR Allergome; 7698; Lup an delta_Conglutin.
DR EnsemblPlants; OIW20800; OIW20800; TanjilG_23180.
DR GeneID; 109338861; -.
DR Gramene; OIW20800; OIW20800; TanjilG_23180.
DR KEGG; lang:109338861; -.
DR OrthoDB; 1646659at2759; -.
DR Proteomes; UP000188354; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0045735; F:nutrient reservoir activity; IEA:InterPro.
DR Gene3D; 1.10.110.10; -; 1.
DR InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR InterPro; IPR000617; Napin/2SS/CON.
DR PANTHER; PTHR35496; PTHR35496; 1.
DR Pfam; PF00234; Tryp_alpha_amyl; 1.
DR SMART; SM00499; AAI; 1.
DR SUPFAM; SSF47699; SSF47699; 1.
PE 1: Evidence at protein level;
KW Allergen; Disulfide bond; Endoplasmic reticulum; Reference proteome;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..153
FT /note="Conglutin delta 2"
FT /id="PRO_5007716036"
FT CHAIN 23..59
FT /note="Conglutin delta-2 small chain"
FT /evidence="ECO:0000250|UniProtKB:F5B8W8"
FT /id="PRO_0000446149"
FT CHAIN 73..153
FT /note="Conglutin delta-2 large chain"
FT /evidence="ECO:0000250|UniProtKB:F5B8W8"
FT /id="PRO_0000446150"
FT DISULFID 30..102
FT /evidence="ECO:0000250|UniProtKB:Q6PSU2"
FT DISULFID 30
FT /note="Interchain (between small and large chains, with C-
FT 102 in large chain)"
FT /evidence="ECO:0000250|UniProtKB:P09930"
FT DISULFID 42..90
FT /note="Or C-45 with C-104"
FT /evidence="ECO:0000250|UniProtKB:Q6PSU2"
FT DISULFID 42
FT /note="Interchain (between small and large chains, with C-
FT 90 or C-91 in large chain)"
FT /evidence="ECO:0000250|UniProtKB:P09930"
FT DISULFID 90
FT /note="Interchain (between small and large chains, with C-
FT 42 in small chain) (or C-91)"
FT /evidence="ECO:0000250|UniProtKB:F5B8W8"
FT DISULFID 91..138
FT /note="Or C-103 with C-152"
FT /evidence="ECO:0000250|UniProtKB:Q6PSU2"
FT DISULFID 91..138
FT /note="Or C-90 with C-65"
FT /evidence="ECO:0000250|UniProtKB:F5B8W8"
FT DISULFID 102
FT /note="Interchain (between small and large chains, with C-
FT 30 in small chain)"
FT /evidence="ECO:0000250|UniProtKB:F5B8W8"
FT DISULFID 104..146
FT /evidence="ECO:0000250|UniProtKB:F5B8W8"
SQ SEQUENCE 153 AA; 17785 MW; A45B7025353F0769 CRC64;
MAKLTILIAL VAALVLVVHT SAFQSSKQSC KRQLQQVNLR HCENHIAQRI QQQQEEEEDH
ALKLRGIKHV ILRHRSSQEY SEESEELDQC CEQLNELNSQ RCQCRALQQI YESQSEQCEG
SQQEQQLEQE LEKLPRTCGF GPLRRCDVNP DEE
