ID   COND3_LUPAN             Reviewed;         149 AA.
AC   F5B8X0;
DT   16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2019, sequence version 2.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Conglutin delta 3 {ECO:0000303|PubMed:21457583};
DE   AltName: Allergen=Lup an delta-conglutin {ECO:0000305};
DE   Contains:
DE     RecName: Full=Conglutin delta-3 large chain {ECO:0000250|UniProtKB:F5B8W8};
DE   Contains:
DE     RecName: Full=Conglutin delta-3 small chain {ECO:0000250|UniProtKB:F5B8W8};
DE   Flags: Precursor;
OS   Lupinus angustifolius (Narrow-leaved blue lupine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   genistoids sensu lato; core genistoids; Genisteae; Lupinus.
OX   NCBI_TaxID=3871;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND ALLERGEN.
RC   STRAIN=cv. Tanjil; TISSUE=Seed;
RX   PubMed=21457583; DOI=10.1186/1471-2229-11-59;
RA   Foley R.C., Gao L.-L., Spriggs A., Soo L.Y.C., Goggin D.E., Smith P.M.C.,
RA   Atkins C.A., Singh K.B.;
RT   "Identification and characterisation of seed storage protein transcripts
RT   from Lupinus angustifolius.";
RL   BMC Plant Biol. 11:59-59(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Tanjil; TISSUE=Seedling;
RX   PubMed=27557478; DOI=10.1111/pbi.12615;
RA   Hane J.K., Ming Y., Kamphuis L.G., Nelson M.N., Garg G., Atkins C.A.,
RA   Bayer P.E., Bravo A., Bringans S., Cannon S., Edwards D., Foley R.,
RA   Gao L.L., Harrison M.J., Huang W., Hurgobin B., Li S., Liu C.W.,
RA   McGrath A., Morahan G., Murray J., Weller J., Jian J., Singh K.B.;
RT   "A comprehensive draft genome sequence for lupin (Lupinus angustifolius),
RT   an emerging health food: insights into plant-microbe interactions and
RT   legume evolution.";
RL   Plant Biotechnol. J. 15:318-330(2017).
CC   -!- SUBUNIT: Heterodimer of a small chain and a large chain; disulfide-
CC       linked. {ECO:0000250|UniProtKB:F5B8W8}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q99235}.
CC   -!- DEVELOPMENTAL STAGE: Accumulates during seed development.
CC       {ECO:0000269|PubMed:21457583}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC       {ECO:0000305|PubMed:21457583}.
CC   -!- SIMILARITY: Belongs to the 2S seed storage albumins family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HQ670420; AEB33723.1; -; mRNA.
DR   EMBL; CM007362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_019420423.1; XM_019564878.1.
DR   AlphaFoldDB; F5B8X0; -.
DR   SMR; F5B8X0; -.
DR   GeneID; 109330626; -.
DR   KEGG; lang:109330626; -.
DR   Proteomes; UP000188354; Chromosome LG02.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:InterPro.
DR   Gene3D; 1.10.110.10; -; 1.
DR   InterPro; IPR036312; Bifun_inhib/LTP/seed_sf.
DR   InterPro; IPR016140; Bifunc_inhib/LTP/seed_store.
DR   InterPro; IPR000617; Napin/2SS/CON.
DR   PANTHER; PTHR35496; PTHR35496; 1.
DR   SMART; SM00499; AAI; 1.
DR   SUPFAM; SSF47699; SSF47699; 1.
PE   2: Evidence at transcript level;
KW   Allergen; Disulfide bond; Endoplasmic reticulum; Reference proteome;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..149
FT                   /note="Conglutin delta 3"
FT                   /id="PRO_5003325734"
FT   CHAIN           23..59
FT                   /note="Conglutin delta-3 small chain"
FT                   /evidence="ECO:0000250|UniProtKB:F5B8W8"
FT                   /id="PRO_0000446151"
FT   CHAIN           73..149
FT                   /note="Conglutin delta-3 large chain"
FT                   /evidence="ECO:0000250|UniProtKB:F5B8W8"
FT                   /id="PRO_0000446152"
FT   DISULFID        30..98
FT                   /evidence="ECO:0000250|UniProtKB:Q6PSU2"
FT   DISULFID        30
FT                   /note="Interchain (between small and large chains, with C-
FT                   98 in large chain)"
FT                   /evidence="ECO:0000250|UniProtKB:P09930"
FT   DISULFID        42..86
FT                   /note="Or C-45 with C-104"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PSU2"
FT   DISULFID        42
FT                   /note="Interchain (between small and large chains, with C-
FT                   86 or C-87 in large chain)"
FT                   /evidence="ECO:0000250|UniProtKB:P09930"
FT   DISULFID        86
FT                   /note="Interchain (between small and large chains, with C-
FT                   42 in small chain) (or C-87)"
FT                   /evidence="ECO:0000250|UniProtKB:F5B8W8"
FT   DISULFID        87..134
FT                   /note="Or C-103 with C-152"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PSU2"
FT   DISULFID        87..134
FT                   /note="Or C-86 with C-134"
FT                   /evidence="ECO:0000250|UniProtKB:F5B8W8"
FT   DISULFID        98
FT                   /note="Interchain (between small and large chains, with C-
FT                   30 in small chain)"
FT                   /evidence="ECO:0000250|UniProtKB:F5B8W8"
FT   DISULFID        100..142
FT                   /evidence="ECO:0000250|UniProtKB:F5B8W8"
FT   CONFLICT        92
FT                   /note="E -> Q (in Ref. 1; AEB33723)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   149 AA;  17407 MW;  A26EC001F4D5F842 CRC64;
     MAKLTILIAL VAALVLVVHT SAFRSSEQSC KRQLQQVNLR HCENHIDQRI QQQQEEEEDR
     ARKLRGIKHV ILRHKSSQES EELDQCCEQL NELNSQRCQC RALQQIYESQ SEQCEGRQQE
     QQLEGELEKL PRICGFGPLR RCNINPDEE