ID   CONGA_CONAV             Reviewed;          18 AA.
AC   P0DOZ2;
DT   12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Conotoxin AusB {ECO:0000303|PubMed:27801785};
OS   Conus australis (Austral cone) (Asprella australis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Phasmoconus.
OX   NCBI_TaxID=1519798;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, DISULFIDE BOND, AND SYNTHESIS.
RC   TISSUE=Venom;
RX   PubMed=27801785; DOI=10.3390/md14110199;
RA   Lebbe E.K., Ghequire M.G., Peigneur S., Mille B.G., Devi P.,
RA   Ravichandran S., Waelkens E., D'Souza L., De Mot R., Tytgat J.;
RT   "Novel conopeptides of largely unexplored indo Pacific Conus sp.";
RL   Mar. Drugs 14:199-216(2016).
CC   -!- FUNCTION: Does not show any effect on voltage-gated sodium, potassium
CC       channels, and on nicotinic acetylcholine receptors (10 uM of toxin
CC       tested) (PubMed:27801785). Does not show antibacterial activity on both
CC       Gram-negative and Gram-positive bacteria (PubMed:27801785).
CC       {ECO:0000269|PubMed:27801785}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27801785}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:27801785}.
CC   -!- DOMAIN: The cysteine framework is C-C. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=2030.8; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:27801785};
CC   -!- MISCELLANEOUS: Does not show effect on Nav1.1, Nav1.2, Nav1.3, Nav1.4,
CC       Nav1.5, Nav1.6, Nav1.8 (PubMed:27801785). Does not show effect on
CC       Kv1.1, Kv1.2, Kv1.3, Kv1.4, Kv1.5, Kv1.6, Kv10.1 and Kv11.1/KCNH2/ERG1
CC       (PubMed:27801785). Does not show effect on muscular (alpha-1-beta-1-
CC       delta-epsilon) and neuronal alpha-7, alpha-4-beta-2, alpha-4-beta-4,
CC       and alpha-3-beta-4 nAChRs (PubMed:27801785).
CC       {ECO:0000269|PubMed:27801785}.
CC   -!- SIMILARITY: Belongs to the ConoGAY family.
CC       {ECO:0000305|PubMed:27801785}.
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DR   AlphaFoldDB; P0DOZ2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   PEPTIDE         1..18
FT                   /note="Conotoxin AusB"
FT                   /evidence="ECO:0000269|PubMed:27801785"
FT                   /id="PRO_0000439364"
FT   DISULFID        11..18
FT                   /evidence="ECO:0000269|PubMed:27801785"
SQ   SEQUENCE   18 AA;  2032 MW;  B86CDCE69DD8705E CRC64;
     GAYFDGFDVP CVPRRDDC