ID   CONG_CONGE              Reviewed;          76 AA.
AC   Q9XYR5;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Contulakin-G;
DE   AltName: Full=CGX-1160;
DE   Flags: Precursor;
OS   Conus geographus (Geography cone) (Nubecula geographus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Gastridium.
OX   NCBI_TaxID=6491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 51-66, PYROGLUTAMATE
RP   FORMATION AT GLN-51, FUNCTION, AND TOXIN TARGET.
RC   TISSUE=Venom;
RX   PubMed=10318778; DOI=10.1074/jbc.274.20.13752;
RA   Craig A.G., Norberg T., Griffin D., Hoeger C., Akhtar M., Schmidt K.,
RA   Low W., Dykert J., Richelson E., Navarro V., Mazella J., Watkins M.,
RA   Hillyard D.R., Imperial J., Cruz L.J., Olivera B.M.;
RT   "Contulakin-G, an O-glycosylated invertebrate neurotensin.";
RL   J. Biol. Chem. 274:13752-13759(1999).
RN   [2]
RP   PHARMACEUTICAL.
RX   PubMed=12507705; DOI=10.1016/s0304-3959(02)00303-2;
RA   Malmberg A.B., Gilbert H., McCabe R.T., Basbaum A.I.;
RT   "Powerful antinociceptive effects of the cone snail venom-derived subtype-
RT   selective NMDA receptor antagonists conantokins G and T.";
RL   Pain 101:109-116(2003).
CC   -!- FUNCTION: Acts as an agonist of neurotensin receptors. It binds to
CC       human neurotensin type 1 receptor (NTSR1), rat neurotensin types 1 and
CC       2 receptors (NTSR1/NTSR2) and mouse neurotensin type 3 receptor
CC       (SORT1). {ECO:0000269|PubMed:10318778}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- PTM: O-glycosylated. The glycosylation seems to enhance the affinity to
CC       the neurotensin receptors.
CC   -!- PHARMACEUTICAL: Is under phase II clinical trials under the name CGX-
CC       1160 by Cognetix Inc. It is efficacious in a wide range of preclinical
CC       pain models (acute, post-surgical, inflammatory, and neuropathic), and
CC       is particularly efficacious in models of chronic pain.
CC   -!- MISCELLANEOUS: The mature peptide does not contain cysteine residue.
CC   -!- SIMILARITY: Belongs to the conotoxin C superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF121108; AAD30031.1; -; mRNA.
DR   PIR; A59043; A59043.
DR   AlphaFoldDB; Q9XYR5; -.
DR   TCDB; 8.B.36.1.3; the contulakin lt (contulakin lt) family.
DR   GlyConnect; 111; 1 O-Linked glycan (1 site).
DR   ConoServer; 1263; contulakin-G precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   G-protein coupled receptor impairing toxin; Glycoprotein; Neurotoxin;
KW   Pharmaceutical; Pyrrolidone carboxylic acid; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..50
FT                   /evidence="ECO:0000269|PubMed:10318778"
FT                   /id="PRO_0000035083"
FT   PEPTIDE         51..66
FT                   /note="Contulakin-G"
FT                   /id="PRO_0000035084"
FT   PROPEP          67..76
FT                   /id="PRO_0000035085"
FT   REGION          51..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         51
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:10318778"
FT   CARBOHYD        60
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /id="CAR_000164"
SQ   SEQUENCE   76 AA;  8261 MW;  D8094EB30C6AAFD4 CRC64;
     MQTAYWVMVM MMVWIAAPLS EGGKLNDVIR GLVPDDITPQ LILGSLISRR QSEEGGSNAT
     KKPYILRASD QVASGP