ID   CONOI_CONVL             Reviewed;           7 AA.
AC   P85015;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   22-APR-2020, entry version 28.
DE   RecName: Full=Conophan vil-I'/vil-I'(O2P) {ECO:0000303|PubMed:17153339};
OS   Conus villepinii (Villepin's cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Dauciconus.
OX   NCBI_TaxID=257347;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, HYDROXYLATION
RP   AT PRO-2, AND D-AMINO ACID AT ILE-5.
RC   TISSUE=Venom;
RX   PubMed=17153339; DOI=10.1007/978-3-540-30880-5_4;
RA   Franco A., Pisarewicz K., Moller C., Mora D., Fields G.B., Mari F.;
RT   "Hyperhydroxylation: a new strategy for neuronal targeting by venomous
RT   marine molluscs.";
RL   Prog. Mol. Subcell. Biol. 43:83-103(2006).
CC   -!- FUNCTION: May act as a neurotoxin.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17153339}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:17153339}.
CC   -!- PTM: Occurs in 2 forms, vil-I' contains 4-hydroxyproline at Pro-2, vil-
CC       I'(O2P) contains unmodified proline at Pro-2.
CC       {ECO:0000269|PubMed:17153339}.
CC   -!- MISCELLANEOUS: The mature peptide does not contain cysteine residue.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conophan family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   D-amino acid; Direct protein sequencing; Hydroxylation; Neurotoxin;
KW   Secreted; Toxin.
FT   PEPTIDE         1..7
FT                   /note="Conophan vil-I'/vil-I'(O2P)"
FT                   /evidence="ECO:0000269|PubMed:17153339"
FT                   /id="PRO_0000259383"
FT   MOD_RES         2
FT                   /note="4-hydroxyproline; in form vil-I'"
FT                   /evidence="ECO:0000269|PubMed:17153339"
FT   MOD_RES         5
FT                   /note="D-allo-isoleucine"
FT                   /evidence="ECO:0000269|PubMed:17153339"
SQ   SEQUENCE   7 AA;  832 MW;  75A37045B4576B70 CRC64;
     EPNSIWS