ID   CONOV_CONVL             Reviewed;           9 AA.
AC   P85141;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   07-OCT-2020, entry version 36.
DE   RecName: Full=Gamma-conopressin vil {ECO:0000303|PubMed:17331075};
OS   Conus villepinii (Villepin's cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Dauciconus.
OX   NCBI_TaxID=257347;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, MASS SPECTROMETRY,
RP   DISULFIDE BOND, GAMMA-CARBOXYGLUTAMATION AT GLU-8, AND AMIDATION AT GLY-9.
RC   TISSUE=Venom;
RX   PubMed=17331075; DOI=10.1042/bj20061480;
RA   Moeller C., Mari F.;
RT   "A vasopressin/oxytocin-related conopeptide with gamma-carboxyglutamate at
RT   position 8.";
RL   Biochem. J. 404:413-419(2007).
CC   -!- FUNCTION: Targets vasopressin-oxytocin related receptors (By
CC       similarity). Binds calcium (PubMed:17331075).
CC       {ECO:0000250|UniProtKB:P0DL76, ECO:0000269|PubMed:17331075}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17331075}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:17331075}.
CC   -!- DOMAIN: The cysteine framework is C-C. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=996.45; Mass_error=0.01; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:17331075};
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   ConoServer; 1307; Gamma-conopressin-vil.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Calcium; Direct protein sequencing; Disulfide bond;
KW   G-protein coupled receptor impairing toxin; Gamma-carboxyglutamic acid;
KW   Metal-binding; Secreted; Toxin.
FT   PEPTIDE         1..9
FT                   /note="Gamma-conopressin vil"
FT                   /evidence="ECO:0000269|PubMed:17331075"
FT                   /id="PRO_0000287675"
FT   MOD_RES         8
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000269|PubMed:17331075"
FT   MOD_RES         9
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:17331075"
FT   DISULFID        1..6
FT                   /evidence="ECO:0000269|PubMed:17331075"
SQ   SEQUENCE   9 AA;  977 MW;  56F4076EBAB6D057 CRC64;
     CLIQDCPEG