ID   CONO_CONMU              Reviewed;           8 AA.
AC   P84701;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   22-APR-2020, entry version 31.
DE   RecName: Full=Conophan mus-V {ECO:0000303|PubMed:15853325};
DE   AltName: Full=Gamma-hydroxyconophan mus-V* {ECO:0000303|PubMed:15853325};
OS   Conus mus (Mouse cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Monteiroconus.
OX   NCBI_TaxID=257335;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, HYDROXYLATION
RP   AT PRO-2 AND VAL-6, D-AMINO ACID AT VAL-6, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=15853325; DOI=10.1021/ja050088m;
RA   Pisarewicz K., Mora D., Pflueger F.C., Fields G.B., Mari F.;
RT   "Polypeptide chains containing D-gamma-hydroxyvaline.";
RL   J. Am. Chem. Soc. 127:6207-6215(2005).
CC   -!- FUNCTION: May act as a neurotoxin.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15853325}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:15853325}.
CC   -!- PTM: Occurs in 2 forms which differ in the post-translational
CC       modification of Val-6. In the form conophan mus-V, Val-6 is D-valine.
CC       In the form gamma-hydroxyconophan mus-V*, Val-6 is D-4-hydroxyvaline.
CC       Both diastereomeric forms of D-hydroxyvaline may be produced.
CC       {ECO:0000269|PubMed:15853325}.
CC   -!- MASS SPECTROMETRY: Mass=863.3; Mass_error=0.1; Method=Electrospray;
CC       Note=Form conophan mus-V.; Evidence={ECO:0000269|PubMed:15853325};
CC   -!- MASS SPECTROMETRY: Mass=879.3; Mass_error=0.1; Method=Electrospray;
CC       Note=Form gamma-hydroxyconophan gld-V*.;
CC       Evidence={ECO:0000269|PubMed:15853325};
CC   -!- MISCELLANEOUS: The mature peptide does not contain cysteine residue.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conophan family. {ECO:0000305}.
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DR   ConoServer; 2481; Conophan-mus-V.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   D-amino acid; Direct protein sequencing; Hydroxylation; Neurotoxin;
KW   Secreted; Toxin.
FT   PEPTIDE         1..8
FT                   /note="Conophan mus-V"
FT                   /evidence="ECO:0000269|PubMed:15853325"
FT                   /id="PRO_0000044125"
FT   MOD_RES         2
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:15853325"
FT   MOD_RES         6
FT                   /note="D-4-hydroxyvaline; in form gamma-hydroxyconophan
FT                   mus-V*"
FT                   /evidence="ECO:0000269|PubMed:15853325"
FT   MOD_RES         6
FT                   /note="D-valine; in form conophan mus-V"
FT                   /evidence="ECO:0000269|PubMed:15853325"
SQ   SEQUENCE   8 AA;  847 MW;  DAA362D5B44DC775 CRC64;
     SPANSVWS