ID   CONO_CONST              Reviewed;           9 AA.
AC   P05487;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Conopressin-S {ECO:0000303|PubMed:18174156};
DE            Short=Con-S {ECO:0000303|PubMed:18174156};
DE   AltName: Full=Arg-conopressin S {ECO:0000303|PubMed:3680228};
OS   Conus striatus (Striated cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=6493;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT GLY-9, DISULFIDE BOND, AND SUBCELLULAR
RP   LOCATION.
RC   TISSUE=Venom;
RX   PubMed=3680228; DOI=10.1016/s0021-9258(18)47661-2;
RA   Cruz L.J., de Santos V., Zafaralla G.C., Ramilo C.A., Zeikus R.D.,
RA   Gray W.R., Olivera B.M.;
RT   "Invertebrate vasopressin/oxytocin homologs. Characterization of peptides
RT   from Conus geographus and Conus striatus venoms.";
RL   J. Biol. Chem. 262:15821-15824(1987).
RN   [2]
RP   FUNCTION.
RX   PubMed=18174156; DOI=10.1074/jbc.m706477200;
RA   Dutertre S., Croker D., Daly N.L., Andersson A., Muttenthaler M.,
RA   Lumsden N.G., Craik D.J., Alewood P.F., Guillon G., Lewis R.J.;
RT   "Conopressin-T from Conus tulipa reveals an antagonist switch in
RT   vasopressin-like peptides.";
RL   J. Biol. Chem. 283:7100-7108(2008).
CC   -!- FUNCTION: Interacts with high affinity with vasopressin V1b receptor
CC       (AVPR1B) (Ki=8.3 nM), although the displacement of specific
CC       [3H]vasopressin binding is incomplete (a 30-40% resistant component
CC       remained). Has weaker affinity binding for oxytocin receptor (OXTR)
CC       (Ki=175 nM), and V1a receptor (AVPR1A) (Ki=827 nM).
CC       {ECO:0000269|PubMed:18174156}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3680228}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:3680228}.
CC   -!- DOMAIN: The cysteine framework is C-C. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Does not interact with V2R (up to 10 uM).
CC       {ECO:0000269|PubMed:18174156}.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   PIR; B28495; B28495.
DR   ConoServer; 1267; conopressin-S.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond;
KW   G-protein coupled receptor impairing toxin; Secreted; Toxin.
FT   PEPTIDE         1..9
FT                   /note="Conopressin-S"
FT                   /evidence="ECO:0000269|PubMed:3680228"
FT                   /id="PRO_0000044099"
FT   MOD_RES         9
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:3680228"
FT   DISULFID        1..6
FT                   /evidence="ECO:0000269|PubMed:3680228"
SQ   SEQUENCE   9 AA;  1031 MW;  17EB176EB4540050 CRC64;
     CIIRNCPRG